Pfn2 - profilin 2 Gene

Also Known as Pfn

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18645

Summary

Predicted to enable ATP hydrolysis activity; Actin monomer binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including modification of postsynaptic Actin cytoskeleton; negative regulation of ruffle assembly; and positive regulation of stress fiber assembly. Acts upstream of or within negative regulation of Actin filament polymerization and positive regulation of Actin filament polymerization. Located in glutamatergic synapse; postsynapse; and terminal bouton. Is active in Schaffer collateral - CA1 synapse and presynapse. Is expressed in several structures, including central nervous system; cornea stroma; ganglia; hemolymphoid system gland; and tooth. Orthologous to human PFN2 (profilin 2). [provided by Alliance of Genome Resources, Apr 2022]

Pfn2 Products (1)

mRNA Protein Name
NM_019410.3 NP_062283.1 profilin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
11826110 MGI
Biological Process GO Annotation Evidence Références Source
involved in modification of postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
26951674 MGI
involved in modification of postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
26951674 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
26951674 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
26951674 MGI
involved in negative regulation of epithelial cell migration IMP
IMP: Inferred from mutant phenotype
23153535 MGI
involved in negative regulation of ruffle assembly IMP
IMP: Inferred from mutant phenotype
23153535 MGI
acts upstream of or within positive regulation of actin filament polymerization IMP
IMP: Inferred from mutant phenotype
17541406 MGI
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
23153535 MGI
involved in positive regulation of stress fiber assembly IMP
IMP: Inferred from mutant phenotype
23153535 MGI
involved in presynaptic actin cytoskeleton organization EXP
EXP: Inferred from Experiment
21976510 MGI
involved in presynaptic actin cytoskeleton organization IDA
IDA: Inferred from direct assay
21976510 MGI
involved in presynaptic actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21976510 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
17541406 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
17541406 MGI
acts upstream of or within regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
17541406 MGI
Cellular Component GO Annotation Evidence Références Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
17541406 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17541406 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17541406 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
17541406 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
17541406 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

profilin-2

  • profilin II

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS10369 PFN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19627 Pfn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20991 Mpeg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26123 Pfn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pfn2 NCBI NCBI:5217