Piga - phosphatidylinositol glycan anchor biosynthesis, class A Gene

Also Known as Pig-a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18700

Summary

Predicted to enable phosphatidylinositol N-acetylglucosaminyltransferase activity. Acts upstream of or within GPI anchor biosynthetic process and cellular response to Leukemia Inhibitory Factor. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Is expressed in 1st branchial arch; central nervous system; heart; limb; and medial-nasal process. Used to study autosomal recessive congenital ichthyosis 4B. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 2 and paroxysmal nocturnal hemoglobinuria. Orthologous to human PIGA (phosphatidylinositol glycan anchor biosynthesis class A). [provided by Alliance of Genome Resources, Apr 2022]

Piga Products (1)

mRNA Protein Name
NM_011081.4 NP_035211.2 phosphatidylinositol N-acetylglucosaminyltransferase subunit A

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within GPI anchor biosynthetic process IMP
IMP: Inferred from mutant phenotype
8611683 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphatidylinositol N-acetylglucosaminyltransferase subunit A

N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein

  • glcNAc-PI synthesis protein

  • phosphatidylinositol glycan, class A

  • phosphatidylinositol-glycan biosynthesis class A protein

  • phosphatidylinositolglycan class A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10487 PIGA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Piga NCBI NCBI:5277