Pik3c2g - phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma Gene

Also Known as PI3K-C2-gamma

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18705

About Pik3c2g

Chromosome 6: 139,564,219-139,915,010 forward strand.GRCm39:CM000999.3

This gene has 15 transcripts (splice variants), 183 orthologues, 9 paralogues and is associated with 13 phenotypes. Biased expression in kidney adult (RPKM 1.6), liver adult (RPKM 1.3) and 13 other tissues.

Summary

Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in chemotaxis. Predicted to be located in Golgi apparatus and nuclear envelope. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in alimentary system; central nervous system; liver; and retina. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PIK3C2G (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma). [provided by Alliance of Genome Resources, Apr 2022]

Pik3c2g Products (2)

mRNA Protein Name
NM_207683.3 NP_997566.2 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform 1
NM_011084.2 NP_035214.2 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 1-phosphatidylinositol-3-kinase activity IDA
IDA: Inferred from direct assay
9514948 MGI
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IDA
IDA: Inferred from direct assay
9514948 MGI
Biological Process GO Annotation Evidence References Source
involved in chemotaxis IMP
IMP: Inferred from mutant phenotype
20536348 MGI
involved in phosphatidylinositol-3-phosphate biosynthetic process IDA
IDA: Inferred from direct assay
9514948 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
9514948 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pik3c2g Protein Structure

C2A_PI3K_class_II

C2A_PI3K_class_II: cd04012 (537 - 697)

PI3Ka

PI3Ka: cl00271 (712 - 879)

PI3Kc_C2_gamma

PI3Kc_C2_gamma: cd05177 (885 - 1238)

PX_PI3K_C2_gamma

PX_PI3K_C2_gamma: cd06896 (1267 - 1367)

C2

C2: cl14603 (1389 - 1501)

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  • 1200
  • 1506 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 3-kinase C2 domain-containing subunit gamma

  • phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide

  • phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma

  • ptdIns-3-kinase C2 subunit gamma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10517 PIK3C2G Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10518 Pik3c2g Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10519 Pik3c2g Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pik3c2g NCBI NCBI:5288