Pou1f1 - POU domain, class 1, transcription factor 1 Gene

Also Known as dw; Hmp1; Pit1; GHF-1; Pit-1; dwarf; Pit1-rs1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18736

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding activity; and sequence-specific DNA binding activity. Acts upstream of or within several processes, including determination of adult lifespan; positive regulation of cellular biosynthetic process; and somatotropin secreting cell development. Located in nucleus. Is expressed in several structures, including eye; genitourinary system; pituitary gland; and trunk somite. Human ortholog(s) of this gene implicated in panhypopituitarism and pituitary gland disease. Orthologous to human POU1F1 (POU class 1 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Pou1f1 Products (2)

mRNA Protein Name
NM_001362468.3 NP_001349397.2 pituitary-specific positive transcription factor 1 isoform w
NM_008849.6 NP_032875.1 pituitary-specific positive transcription factor 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
10367888 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
9305891 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
11891224 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
16678101 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10367888 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7902581 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell differentiation IMP
IMP: Inferred from mutant phenotype
9300691 MGI
acts upstream of or within cell fate specification IDA
IDA: Inferred from direct assay
10367888 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16556738 MGI
acts upstream of or within determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
11371619 MGI
acts upstream of inositol trisphosphate biosynthetic process IMP
IMP: Inferred from mutant phenotype
11371619 MGI
acts upstream of or within pituitary gland development IMP
IMP: Inferred from mutant phenotype
16556738 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11891224 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16556738 MGI
acts upstream of or within positive regulation of inositol trisphosphate biosynthetic process IMP
IMP: Inferred from mutant phenotype
11371619 MGI
acts upstream of or within positive regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
7390396 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8391647 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
9305891 MGI
acts upstream of or within regulation of insulin-like growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
7390396 MGI
acts upstream of or within somatotropin secreting cell development IMP
IMP: Inferred from mutant phenotype
17015435 MGI
acts upstream of or within somatotropin secreting cell differentiation IMP
IMP: Inferred from mutant phenotype
1334535 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12651892 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pituitary-specific positive transcription factor 1

  • POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)

  • pituitary specific transcription factor 1, related sequence 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10895 POU1F1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pou1f1 NCBI NCBI:5449