Pou1f1 - POU domain, class 1, transcription factor 1 Gene

Mus musculus

Also known as dw; Hmp1; Pit1; GHF-1; Pit-1; dwarf; Pit1-rs1

Gene ID: 18736 | Gene type: protein coding

About Pou1f1

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding activity; and sequence-specific DNA binding activity. Acts upstream of or within several processes, including determination of adult lifespan; positive regulation of cellular biosynthetic process; and somatotropin secreting cell development. Located in nucleus. Is expressed in several structures, including eye; genitourinary system; pituitary gland; and trunk somite. Human ortholog(s) of this gene implicated in panhypopituitarism and pituitary gland disease. Orthologous to human POU1F1 (POU class 1 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Pou1f1 Products(2)

mRNA	Protein	Name
NM_001362468.3	NP_001349397.2	pituitary-specific positive transcription factor 1 isoform w
NM_008849.6	NP_032875.1	pituitary-specific positive transcription factor 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	10367888	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9305891	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11891224	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16678101	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10367888	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7902581	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell differentiation	IMP IMP: Inferred from mutant phenotype	9300691	MGI
acts upstream of or within cell fate specification	IDA IDA: Inferred from direct assay	10367888	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16556738	MGI
acts upstream of or within determination of adult lifespan	IMP IMP: Inferred from mutant phenotype	11371619	MGI
acts upstream of inositol trisphosphate biosynthetic process	IMP IMP: Inferred from mutant phenotype	11371619	MGI
acts upstream of or within pituitary gland development	IMP IMP: Inferred from mutant phenotype	16556738	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11891224	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16556738	MGI
acts upstream of or within positive regulation of inositol trisphosphate biosynthetic process	IMP IMP: Inferred from mutant phenotype	11371619	MGI
acts upstream of or within positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	7390396	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8391647	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9305891	MGI
acts upstream of or within regulation of insulin-like growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	7390396	MGI
acts upstream of or within somatotropin secreting cell development	IMP IMP: Inferred from mutant phenotype	17015435	MGI
acts upstream of or within somatotropin secreting cell differentiation	IMP IMP: Inferred from mutant phenotype	1334535	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12651892	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pituitary-specific positive transcription factor 1

POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)

pituitary specific transcription factor 1, related sequence 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10895	POU1F1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pou1f1	NCBI	NCBI:5449

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