Pknox1 - Pbx/knotted 1 homeobox Gene

Also Known as PREP1; D17Wsu76e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18771

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including angiogenesis; hemopoiesis; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Orthologous to human PKNOX1 (PBX/knotted 1 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Pknox1 Products (16)

mRNA Protein Name
NM_001411456.1 NP_001398385.1 homeobox protein PKNOX1 isoform 1
NM_001411457.1 NP_001398386.1 homeobox protein PKNOX1 isoform 1
NM_001411458.1 NP_001398387.1 homeobox protein PKNOX1 isoform 1
NM_001411459.1 NP_001398388.1 homeobox protein PKNOX1 isoform 1
NM_001411460.1 NP_001398389.1 homeobox protein PKNOX1 isoform 2
NM_001411461.1 NP_001398390.1 homeobox protein PKNOX1 isoform 2
NM_001411462.1 NP_001398391.1 homeobox protein PKNOX1 isoform 2
NM_001411463.1 NP_001398392.1 homeobox protein PKNOX1 isoform 2
NM_001411464.1 NP_001398393.1 homeobox protein PKNOX1 isoform 3
NM_001411465.1 NP_001398394.1 homeobox protein PKNOX1 isoform 3
NM_001411466.1 NP_001398395.1 homeobox protein PKNOX1 isoform 4
NM_001411467.1 NP_001398396.1 homeobox protein PKNOX1 isoform 5
NM_001411468.1 NP_001398397.1 homeobox protein PKNOX1 isoform 6
NM_001411469.1 NP_001398398.1 homeobox protein PKNOX1 isoform 6
NM_001411864.1 NP_001398793.1 homeobox protein PKNOX1 isoform 1
NM_016670.4 NP_057879.2 homeobox protein PKNOX1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
9405651 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10373562 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10381567 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IGI
IGI: Inferred from genetic interaction
17049510 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
22780989 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9405651 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17875925 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell differentiation IMP
IMP: Inferred from mutant phenotype
16314502 MGI
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
16847320 MGI
acts upstream of or within camera-type eye development IMP
IMP: Inferred from mutant phenotype
16847320 MGI
acts upstream of or within erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
16847320 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
17904118 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10381567 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10373562 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15087118 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15087118 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
9405651 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein PKNOX1

  • PBX/knotted homeobox 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10609 PKNOX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pknox1 NCBI NCBI:5316