Plxna3 - plexin A3 Gene

Mus musculus

Also known as SEX; Plxa3; Plxn3; Plxn4; PlexA3; mKIAA4078

Gene ID: 18846 | Gene type: protein coding

About Plxna3

Summary

Enables semaphorin receptor activity. Involved in nervous system development and positive regulation of Cytoskeleton organization. Acts upstream of or within generation of neurons; hippocampus development; and negative chemotaxis. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of semaphorin receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human PLXNA3 (plexin A3). [provided by Alliance of Genome Resources, Apr 2022]

Plxna3 Products(2)

mRNA	Protein	Name
NM_001358129.1	NP_001345058.1	plexin-A3 isoform 2 precursor
NM_008883.2	NP_032909.2	plexin-A3 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables semaphorin receptor activity	IMP IMP: Inferred from mutant phenotype	19717441	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of axon extension involved in axon guidance	IGI IGI: Inferred from genetic interaction	11683995	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	11683995	MGI
involved in branchiomotor neuron axon guidance	IMP IMP: Inferred from mutant phenotype	18804103	MGI
involved in facial nerve structural organization	IMP IMP: Inferred from mutant phenotype	18804103	MGI
involved in gonadotrophin-releasing hormone neuronal migration to the hypothalamus	IGI IGI: Inferred from genetic interaction	31690636	MGI
acts upstream of or within hippocampus development	IMP IMP: Inferred from mutant phenotype	11683995	MGI
acts upstream of or within negative chemotaxis	IGI IGI: Inferred from genetic interaction	11683995	MGI
acts upstream of or within negative regulation of axon extension involved in axon guidance	IGI IGI: Inferred from genetic interaction	11683995	MGI
acts upstream of or within neuron projection extension	IGI IGI: Inferred from genetic interaction	21835343	MGI
acts upstream of or within neuron projection guidance	IMP IMP: Inferred from mutant phenotype	21835343	MGI
involved in olfactory nerve formation	IGI IGI: Inferred from genetic interaction	31690636	MGI
involved in positive regulation of cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	19717441	MGI
acts upstream of or within pyramidal neuron development	IMP IMP: Inferred from mutant phenotype	11683995	MGI
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	18804103	MGI
involved in trigeminal nerve structural organization	IMP IMP: Inferred from mutant phenotype	18804103	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

plexin-A3

plexin 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10750	PLXNA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plxna3	NCBI	NCBI:55558

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