Pou3f4 - POU domain, class 3, transcription factor 4 Gene

Mus musculus

Also known as Slf; Brn4; Otf9; Brn-4; OTF-9; oct-9

Gene ID: 18994 | Gene type: protein coding

About Pou3f4

Summary

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cochlea morphogenesis and negative regulation of mesenchymal cell apoptotic process. Acts upstream of or within forebrain neuron differentiation; inner ear development; and sensory perception of sound. Predicted to be located in nucleoplasm. Is expressed in several structures, including brain; cranium; ear; embryo ectoderm; and foregut-midgut junction. Human ortholog(s) of this gene implicated in X-linked deafness 2. Orthologous to human POU3F4 (POU class 3 homeobox 4). [provided by Alliance of Genome Resources, Apr 2022]

Pou3f4 Products(1)

mRNA	Protein	Name
NM_008901.2	NP_032927.1	POU domain, class 3, transcription factor 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17141158	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17141158	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cochlea morphogenesis	IGI IGI: Inferred from genetic interaction	18231833	MGI
acts upstream of or within forebrain neuron differentiation	IMP IMP: Inferred from mutant phenotype	9889200	MGI
acts upstream of or within inner ear development	IMP IMP: Inferred from mutant phenotype	10587581	MGI
involved in negative regulation of mesenchymal cell apoptotic process	IGI IGI: Inferred from genetic interaction	18231833	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	10587581	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	10868931	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

POU domain, class 3, transcription factor 4

brain-4 class III POU-domain protein	brain-specific homeobox/POU domain protein 4
octamer-binding protein 9	octamer-binding transcription factor 9
sex linked fidget

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10903	POU3F4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pou3f4	NCBI	NCBI:5456

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