Pou3f4 - POU domain, class 3, transcription factor 4 Gene

Also Known as Slf; Brn4; Otf9; Brn-4; OTF-9; oct-9

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18994

Summary

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cochlea morphogenesis and negative regulation of mesenchymal cell apoptotic process. Acts upstream of or within forebrain neuron differentiation; inner ear development; and sensory perception of sound. Predicted to be located in nucleoplasm. Is expressed in several structures, including brain; cranium; ear; embryo ectoderm; and foregut-midgut junction. Human ortholog(s) of this gene implicated in X-linked deafness 2. Orthologous to human POU3F4 (POU class 3 homeobox 4). [provided by Alliance of Genome Resources, Apr 2022]

Pou3f4 Products (1)

mRNA Protein Name
NM_008901.2 NP_032927.1 POU domain, class 3, transcription factor 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17141158 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17141158 MGI
Biological Process GO Annotation Evidence References Source
involved in cochlea morphogenesis IGI
IGI: Inferred from genetic interaction
18231833 MGI
acts upstream of or within forebrain neuron differentiation IMP
IMP: Inferred from mutant phenotype
9889200 MGI
acts upstream of or within inner ear development IMP
IMP: Inferred from mutant phenotype
10587581 MGI
involved in negative regulation of mesenchymal cell apoptotic process IGI
IGI: Inferred from genetic interaction
18231833 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
10587581 MGI
Cellular Component GO Annotation Evidence References Source
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
10868931 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

POU domain, class 3, transcription factor 4

  • brain-4 class III POU-domain protein

  • brain-specific homeobox/POU domain protein 4

  • octamer-binding protein 9

  • octamer-binding transcription factor 9

  • sex linked fidget

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10903 POU3F4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pou3f4 NCBI NCBI:5456