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Pou4f2 - POU domain, class 4, transcription factor 2 Gene

Also Known as Brn3b; Brn-3b; Brn-3.2; mBrn3-3R; Pou4f-rs1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18997

Summary

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; p53 binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to estradiol stimulus; positive regulation of cell differentiation; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including axonogenesis; neuromuscular process controlling balance; and sensory perception of sound. Located in cytoplasm; euchromatin; and nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; glomerular tuft; sensory organ; and trunk. Orthologous to human POU4F2 (POU class 4 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Pou4f2 Products (1)

mRNA	Protein	Name
NM_138944.3	NP_620394.2	POU domain, class 4, transcription factor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17145718	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	17145718	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	21875655	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8670054	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	26670484	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	18434421	MGI
enables p53 binding	IPI IPI: Inferred from physical interaction	17145718	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	17145718	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8537352	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7904822	MGI
enables sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	8290353	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within axon extension	IGI IGI: Inferred from genetic interaction	11807038	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	11163266	MGI
acts upstream of or within axonogenesis	IMP IMP: Inferred from mutant phenotype	10357904	MGI
involved in cellular response to cytokine stimulus	IDA IDA: Inferred from direct assay	17668438	MGI
involved in cellular response to estradiol stimulus	IDA IDA: Inferred from direct assay	9448000	MGI
involved in cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	26670484	MGI
involved in dorsal root ganglion development	IMP IMP: Inferred from mutant phenotype	10357904	MGI
involved in heart development	IGI IGI: Inferred from genetic interaction	28594399	MGI
involved in intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	17145718	MGI
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	8537352	MGI
involved in negative regulation of adipose tissue development	IMP IMP: Inferred from mutant phenotype	26670484	MGI
involved in negative regulation of amacrine cell differentiation	IMP IMP: Inferred from mutant phenotype	21875655	MGI
involved in negative regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	21875655	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8670054	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18367606	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	7935408	MGI
acts upstream of or within neuromuscular process controlling balance	IGI IGI: Inferred from genetic interaction	11807038	MGI
acts upstream of or within neuron differentiation	IGI IGI: Inferred from genetic interaction	18434421	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	8637595	MGI
involved in positive regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	26670484	MGI
involved in positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	10357904	MGI
acts upstream of or within positive regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	18367606	MGI
involved in positive regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	21875655	MGI
involved in positive regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	17668438	MGI
involved in positive regulation of programmed cell death	IMP IMP: Inferred from mutant phenotype	17145718	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18434421	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17145718	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	18434421	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	7904822	MGI
involved in positive regulation of transcription regulatory region DNA binding	IDA IDA: Inferred from direct assay	9448000	MGI
involved in regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	9448000	MGI
involved in regulation of retinal ganglion cell axon guidance	IMP IMP: Inferred from mutant phenotype	11163266	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	8637595	MGI
acts upstream of or within retinal ganglion cell axon guidance	IGI IGI: Inferred from genetic interaction	11807038	MGI
acts upstream of or within retinal ganglion cell axon guidance	IMP IMP: Inferred from mutant phenotype	18434421	MGI
acts upstream of or within sensory perception of sound	IGI IGI: Inferred from genetic interaction	11807038	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17668438	MGI
located in euchromatin	IDA IDA: Inferred from direct assay	26670484	MGI
located in nucleus	IDA IDA: Inferred from direct assay	7623109	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
POU domain, class 4, transcription factor 2	POU domain, class 4, transcription factor, related sequence 1 brain-3B brain-specific homeobox/POU domain protein 3B

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10905	POU4F2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pou4f2	NCBI	NCBI:5458