Pou4f3 - POU domain, class 4, transcription factor 3 Gene

Mus musculus

Also known as ddl; Brn3c; Brn3.1; dreidel

Gene ID: 18998 | Gene type: protein coding

About Pou4f3

Summary

Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including nervous system development; neuromuscular process controlling balance; and sensory perception of sound. Located in nucleus. Is expressed in several structures, including genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 15 and autosomal dominant nonsyndromic deafness 52. Orthologous to human POU4F3 (POU class 4 homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]

Pou4f3 Products(1)

mRNA	Protein	Name
NM_138945.2	NP_620395.2	POU domain, class 4, transcription factor 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15465029	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	24643061	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7935408	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axon extension	IGI IGI: Inferred from genetic interaction	11807038	MGI
acts upstream of or within inner ear auditory receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	8637595	MGI
acts upstream of or within inner ear development	IMP IMP: Inferred from mutant phenotype	9256502	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	12585968	MGI
acts upstream of or within inner ear receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	9256502	MGI
acts upstream of or within neuromuscular process controlling balance	IGI IGI: Inferred from genetic interaction	11807038	MGI
acts upstream of or within neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	8637595	MGI
acts upstream of or within neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9735355	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	7935408	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15465029	MGI
acts upstream of or within retinal ganglion cell axon guidance	IGI IGI: Inferred from genetic interaction	11807038	MGI
acts upstream of or within sensory perception of sound	IGI IGI: Inferred from genetic interaction	11807038	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	8637595	MGI
acts upstream of or within vestibulocochlear nerve development	IMP IMP: Inferred from mutant phenotype	12585968	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	7623109	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

POU domain, class 4, transcription factor 3

brain-3C	brain-specific homeobox POU domain protein 3C
brn-3C

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10906	POU4F3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pou4f3	NCBI	NCBI:5459

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