Pou4f3 - POU domain, class 4, transcription factor 3 Gene

Also Known as ddl; Brn3c; Brn3.1; dreidel

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18998

Summary

Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including nervous system development; neuromuscular process controlling balance; and sensory perception of sound. Located in nucleus. Is expressed in several structures, including genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 15 and autosomal dominant nonsyndromic deafness 52. Orthologous to human POU4F3 (POU class 4 homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]

Pou4f3 Products (1)

mRNA Protein Name
NM_138945.2 NP_620395.2 POU domain, class 4, transcription factor 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15465029 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24643061 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7935408 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axon extension IGI
IGI: Inferred from genetic interaction
11807038 MGI
acts upstream of or within inner ear auditory receptor cell differentiation IMP
IMP: Inferred from mutant phenotype
8637595 MGI
acts upstream of or within inner ear development IMP
IMP: Inferred from mutant phenotype
9256502 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
12585968 MGI
acts upstream of or within inner ear receptor cell differentiation IMP
IMP: Inferred from mutant phenotype
9256502 MGI
acts upstream of or within neuromuscular process controlling balance IGI
IGI: Inferred from genetic interaction
11807038 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
8637595 MGI
acts upstream of or within neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
9735355 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
7935408 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15465029 MGI
acts upstream of or within retinal ganglion cell axon guidance IGI
IGI: Inferred from genetic interaction
11807038 MGI
acts upstream of or within sensory perception of sound IGI
IGI: Inferred from genetic interaction
11807038 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
8637595 MGI
acts upstream of or within vestibulocochlear nerve development IMP
IMP: Inferred from mutant phenotype
12585968 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
7623109 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

POU domain, class 4, transcription factor 3

  • brain-3C

  • brain-specific homeobox POU domain protein 3C

  • brn-3C

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10906 POU4F3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pou4f3 NCBI NCBI:5459