Ppox - protoporphyrinogen oxidase Gene

Also Known as Ppo

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19044

Summary

Enables oxygen-dependent protoporphyrinogen oxidase activity. Acts upstream of or within heme biosynthetic process. Is intrinsic component of mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study variegate porphyria. Human ortholog(s) of this gene implicated in variegate porphyria. Orthologous to human PPOX (protoporphyrinogen oxidase). [provided by Alliance of Genome Resources, Apr 2022]

Ppox Products (1)

mRNA Protein Name
NM_008911.2 NP_032937.1 protoporphyrinogen oxidase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables oxygen-dependent protoporphyrinogen oxidase activity IDA
IDA: Inferred from direct assay
3346226 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
34354145 MGI
Biological Process GO Annotation Evidence References Source
involved in heme A biosynthetic process IDA
IDA: Inferred from direct assay
3346226 MGI
involved in heme B biosynthetic process IDA
IDA: Inferred from direct assay
3346226 MGI
involved in heme O biosynthetic process IDA
IDA: Inferred from direct assay
3346226 MGI
acts upstream of or within heme biosynthetic process IDA
IDA: Inferred from direct assay
3346226 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
3346226 MGI
is active in mitochondrial intermembrane space IDA
IDA: Inferred from direct assay
2451512 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protoporphyrinogen oxidase

  • protoporhyrinogen oxidase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10972 PPOX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-12464 Butafenacil 98.99% Unkown
HY-RS06050 HCRT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18943 Hcrt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppox NCBI NCBI:5498