Ppp1ca - protein phosphatase 1 catalytic subunit alpha Gene

Also Known as Ppp1c; dism2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19045

Summary

Enables protein serine/threonine Phosphatase activity. Involved in circadian regulation of gene expression and entrainment of circadian clock by photoperiod. Acts upstream of or within several processes, including branching morphogenesis of an epithelial tube; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; and protein dephosphorylation. Located in cytoplasm and nucleoplasm. Is expressed in several structures, including esophagus; eye; and respiratory system. Orthologous to human PPP1CA (protein Phosphatase 1 catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppp1ca Products (1)

mRNA	Protein	Name
NM_031868.2	NP_114074.1	serine/threonine-protein phosphatase PP1-alpha catalytic subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatase activity	IDA IDA: Inferred from direct assay	21930935	MGI
enables phosphoprotein phosphatase activity	IDA IDA: Inferred from direct assay	14580336	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12115603	MGI
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	12115603	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within branching morphogenesis of an epithelial tube	IMP IMP: Inferred from mutant phenotype	15042703	MGI
involved in circadian regulation of gene expression	IDA IDA: Inferred from direct assay	21930935	MGI
involved in entrainment of circadian clock by photoperiod	IMP IMP: Inferred from mutant phenotype	21712997	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	15042703	MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	12115603	MGI
involved in positive regulation of glycogen biosynthetic process	IMP IMP: Inferred from mutant phenotype	31553910	MGI
acts upstream of or within protein dephosphorylation	IDA IDA: Inferred from direct assay	12115603	MGI
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	21930935	MGI
involved in regulation of circadian rhythm	IDA IDA: Inferred from direct assay	21930935	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	21712997	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9882488	MGI
located in nucleoplasm	IDA IDA: Inferred from direct assay	9882488	MGI
located in nucleus	IDA IDA: Inferred from direct assay	21471512	MGI
part of protein phosphatase type 1 complex	IMP IMP: Inferred from mutant phenotype	31553910	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
serine/threonine-protein phosphatase PP1-alpha catalytic subunit	PP-1A

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10973	PPP1CA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppp1ca	NCBI	NCBI:5499