Ppp1cb - protein phosphatase 1 catalytic subunit beta Gene

Mus musculus

Also known as 1200010B19

Gene ID: 19046 | Gene type: protein coding

About Ppp1cb

Summary

Enables protein serine/threonine Phosphatase activity. Involved in circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and protein dephosphorylation. Located in cytoplasm. Is expressed in cornea; lens epithelium; lens fiber; limb; and retina. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 2. Orthologous to human PPP1CB (protein Phosphatase 1 catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Ppp1cb Products(1)

mRNA	Protein	Name
NM_172707.3	NP_766295.2	serine/threonine-protein phosphatase PP1-beta catalytic subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatase activity	IDA IDA: Inferred from direct assay	21930935	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21471512	MGI
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	14640981	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian regulation of gene expression	IDA IDA: Inferred from direct assay	21930935	MGI
involved in entrainment of circadian clock by photoperiod	IMP IMP: Inferred from mutant phenotype	21712997	MGI
acts upstream of or within protein dephosphorylation	IDA IDA: Inferred from direct assay	14640981	MGI
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	21930935	MGI
involved in regulation of circadian rhythm	IDA IDA: Inferred from direct assay	21930935	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	21712997	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21471512	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase PP1-beta catalytic subunit

PP-1B

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10974	PPP1CB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppp1cb	NCBI	NCBI:5500

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