Ppp2cb - protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform Gene

Also Known as PP2Ac; D8Ertd766e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19053

Summary

Predicted to enable protein C-terminus binding activity and protein serine/threonine Phosphatase activity. Acts upstream of or within several processes, including apoptotic mitochondrial changes; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to hydrogen peroxide. Located in cytoplasm. Part of protein Phosphatase type 2A complex. Is expressed in several structures, including cardiovascular system; eye; genitourinary system; gut; and nervous system. Orthologous to human PPP2CB (protein Phosphatase 2 catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Ppp2cb Products (1)

mRNA Protein Name
NM_017374.3 NP_059070.1 serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12885400 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within apoptotic mitochondrial changes IMP
IMP: Inferred from mutant phenotype
16717086 MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
16717086 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
16717086 MGI
acts upstream of or within response to antibiotic IMP
IMP: Inferred from mutant phenotype
16717086 MGI
acts upstream of or within response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
16717086 MGI
acts upstream of or within response to hydrogen peroxide IMP
IMP: Inferred from mutant phenotype
16717086 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10781942 MGI
part of protein phosphatase type 2A complex IDA
IDA: Inferred from direct assay
16717086 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

  • PP2A-beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11008 PPP2CB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppp2cb NCBI NCBI:5516