Ppp3cc - protein phosphatase 3, catalytic subunit, gamma isoform Gene

Mus musculus

Also known as Calnc; PP2BA gamma

Gene ID: 19057 | Gene type: protein coding

About Ppp3cc

Summary

Predicted to enable Calmodulin binding activity and calmodulin-dependent protein Phosphatase activity. Predicted to be involved in calcineurin-NFAT signaling cascade; positive regulation of synaptic vesicle endocytosis; and protein dephosphorylation. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in gastrocnemius muscle; ovary; and renal vasculature. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PPP3CC (protein Phosphatase 3 catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]

Ppp3cc Products(4)

mRNA	Protein	Name
NM_001304991.1	NP_001291920.1	serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 1
NM_001304992.1	NP_001291921.1	serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 3
NM_001360229.1	NP_001347158.1	serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 4
NM_008915.3	NP_032941.1	serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-dependent protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	26429887	MGI
enables calcium-dependent protein serine/threonine phosphatase activity	IMP IMP: Inferred from mutant phenotype	26429887	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	31696965	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within penetration of zona pellucida	IMP IMP: Inferred from mutant phenotype	26429887	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of calcineurin complex	IDA IDA: Inferred from direct assay	1325794	MGI
part of calcineurin complex	IGI IGI: Inferred from genetic interaction	26429887	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	26627835	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	34446558	MGI
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	26627835	MGI
located in sperm flagellum	IDA IDA: Inferred from direct assay	26429887	MGI
located in sperm midpiece	IDA IDA: Inferred from direct assay	34446558	MGI
located in sperm mitochondrial sheath	IDA IDA: Inferred from direct assay	34446558	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

CAM-PRP catalytic subunit

calcineurin, testis-specific catalytic subunit

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11025	PPP3CC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppp3cc	NCBI	NCBI:5533

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