Ppp3cc - protein phosphatase 3, catalytic subunit, gamma isoform Gene

Also Known as Calnc; PP2BA gamma

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19057

Summary

Predicted to enable Calmodulin binding activity and calmodulin-dependent protein Phosphatase activity. Predicted to be involved in calcineurin-NFAT signaling cascade; positive regulation of synaptic vesicle endocytosis; and protein dephosphorylation. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in gastrocnemius muscle; ovary; and renal vasculature. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PPP3CC (protein Phosphatase 3 catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]

Ppp3cc Products (4)

mRNA Protein Name
NM_001304991.1 NP_001291920.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 1
NM_001304992.1 NP_001291921.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 3
NM_001360229.1 NP_001347158.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 4
NM_008915.3 NP_032941.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent protein serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
26429887 MGI
enables calcium-dependent protein serine/threonine phosphatase activity IMP
IMP: Inferred from mutant phenotype
26429887 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
31696965 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within penetration of zona pellucida IMP
IMP: Inferred from mutant phenotype
26429887 MGI
Cellular Component GO Annotation Evidence References Source
part of calcineurin complex IDA
IDA: Inferred from direct assay
1325794 MGI
part of calcineurin complex IGI
IGI: Inferred from genetic interaction
26429887 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
26627835 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
34446558 MGI
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
26627835 MGI
located in sperm flagellum IDA
IDA: Inferred from direct assay
26429887 MGI
located in sperm midpiece IDA
IDA: Inferred from direct assay
34446558 MGI
located in sperm mitochondrial sheath IDA
IDA: Inferred from direct assay
34446558 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

  • CAM-PRP catalytic subunit

  • calcineurin, testis-specific catalytic subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11025 PPP3CC Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppp3cc NCBI NCBI:5533