Prkar1b - protein kinase, cAMP dependent regulatory, type I beta Gene

Mus musculus

Also known as RIbeta

Gene ID: 19085 | Gene type: protein coding

About Prkar1b

Summary

Predicted to enable cAMP binding activity; cAMP-dependent protein kinase inhibitor activity; and protein kinase A catalytic subunit binding activity. Involved in modulation of chemical synaptic transmission and regulation of synaptic vesicle cycle. Acts upstream of or within learning or memory. Located in hippocampal mossy fiber to CA3 synapse and multivesicular body. Part of cAMP-dependent protein kinase complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Orthologous to human PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Prkar1b Products(7)

mRNA	Protein	Name
NM_001253890.1	NP_001240819.1	cAMP-dependent protein kinase type I-beta regulatory subunit isoform a
NM_001359097.1	NP_001346026.1	cAMP-dependent protein kinase type I-beta regulatory subunit isoform a
NM_001359098.1	NP_001346027.1	cAMP-dependent protein kinase type I-beta regulatory subunit isoform a
NM_001359099.1	NP_001346028.1	cAMP-dependent protein kinase type I-beta regulatory subunit isoform a
NM_001359100.1	NP_001346029.1	cAMP-dependent protein kinase type I-beta regulatory subunit isoform a
NM_001359101.1	NP_001346030.1	cAMP-dependent protein kinase type I-beta regulatory subunit isoform b
NM_008923.3	NP_032949.3	cAMP-dependent protein kinase type I-beta regulatory subunit isoform a

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within learning or memory	IMP IMP: Inferred from mutant phenotype	7568030	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	7568030	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	7568030	MGI
involved in regulation of synaptic vesicle cycle	IDA IDA: Inferred from direct assay	8548807	MGI
involved in regulation of synaptic vesicle cycle	IMP IMP: Inferred from mutant phenotype	8548807	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	7568030	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	7568030	MGI
part of cAMP-dependent protein kinase complex	IDA IDA: Inferred from direct assay	21502359	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	21502359	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	24413018	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	7568030	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	7568030	MGI
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	8548807	MGI
is active in hippocampal mossy fiber to CA3 synapse	IMP IMP: Inferred from mutant phenotype	8548807	MGI
located in multivesicular body	IDA IDA: Inferred from direct assay	21502359	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	19447092	MGI
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	19447092	MGI
is active in synapse	EXP EXP: Inferred from Experiment	24413018	MGI
is active in synapse	IDA IDA: Inferred from direct assay	24413018	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cAMP-dependent protein kinase type I-beta regulatory subunit

cAMP dependent regulatory type I beta subunit transcript 1	cAMP dependent regulatory type I beta subunit transcript 2
cAMP dependent regulatory type I beta subunit transcript 3	cAMP dependent regulatory type I beta subunit transcript 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11113	PRKAR1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkar1b	NCBI	NCBI:5575

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