Prkcsh - protein kinase C substrate 80K-H Gene

Also Known as 80K-H; PKCSH

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19089

Summary

Enables RNA binding activity and calcium ion binding activity. Acts upstream of or within several processes, including in utero embryonic development; liver development; and negative regulation of neuron projection development. Part of glucosidase II complex. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and hemolymphoid system gland. Used to study polycystic liver disease. Human ortholog(s) of this gene implicated in liver disease and polycystic liver disease. Orthologous to human PRKCSH (protein kinase C substrate 80K-H). [provided by Alliance of Genome Resources, Apr 2022]

Prkcsh Products (3)

mRNA Protein Name
NM_001293650.1 NP_001280579.1 glucosidase 2 subunit beta isoform 1 precursor
NM_001293651.1 NP_001280580.1 glucosidase 2 subunit beta isoform 2 precursor
NM_008925.2 NP_032951.1 glucosidase 2 subunit beta isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
16706842 MGI
enables calcium ion binding IDA
IDA: Inferred from direct assay
27462106 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9148925 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
21685914 MGI
acts upstream of or within liver development IGI
IGI: Inferred from genetic interaction
21685914 MGI
acts upstream of or within negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
22337885 MGI
acts upstream of or within nitrogen cycle metabolic process IGI
IGI: Inferred from genetic interaction
21685914 MGI
Cellular Component GO Annotation Evidence References Source
part of glucosidase II complex IDA
IDA: Inferred from direct assay
27462106 MGI
part of glucosidase II complex IPI
IPI: Inferred from physical interaction
9148925 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glucosidase 2 subunit beta

  • alpha glucosidase II, beta-subunit

  • carbohydrate processing enzyme of the endoplasmic reticulum

  • glucosidase II beta-subunit

  • hepatocystin

  • protein kinase C substrate 60.1 kDa protein heavy chain

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11140 PRKCSH Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkcsh NCBI NCBI:5589