Prss12 - protease, serine 12 neurotrypsin (motopsin) Gene

Also Known as Bssp-3; motopsin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19142

Summary

Enables serine-type endopeptidase activity. Involved in exocytosis. Acts upstream of or within zymogen activation. Located in several cellular components, including dendrite; synaptic cleft; and terminal bouton. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and intellectual disability. Orthologous to human PRSS12 (serine protease 12). [provided by Alliance of Genome Resources, Apr 2022]

Prss12 Products (1)

mRNA Protein Name
NM_008939.2 NP_032965.1 neurotrypsin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peptidase activity IMP
IMP: Inferred from mutant phenotype
17586728 MGI
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
17223089 MGI
Biological Process GO Annotation Evidence References Source
involved in exocytosis IDA
IDA: Inferred from direct assay
18272678 MGI
acts upstream of or within proteolysis IDA
IDA: Inferred from direct assay
17223089 MGI
acts upstream of or within proteolysis IMP
IMP: Inferred from mutant phenotype
17586728 MGI
acts upstream of or within zymogen activation IDA
IDA: Inferred from direct assay
17223089 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
18230682 MGI
located in axon IDA
IDA: Inferred from direct assay
18272678 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
17223089 MGI
located in dendrite IDA
IDA: Inferred from direct assay
17223089 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
18230682 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18272678 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
18230682 MGI
located in synapse IDA
IDA: Inferred from direct assay
18230682 MGI
located in synaptic cleft IDA
IDA: Inferred from direct assay
18272678 MGI
located in terminal bouton IDA
IDA: Inferred from direct assay
18272678 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurotrypsin

  • brain-specific serine protease 3

  • serine protease 12

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11246 PRSS12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prss12 NCBI NCBI:8492