Prss12 - protease, serine 12 neurotrypsin (motopsin) Gene

Mus musculus

Also known as Bssp-3; motopsin

Gene ID: 19142 | Gene type: protein coding

About Prss12

Summary

Enables serine-type endopeptidase activity. Involved in exocytosis. Acts upstream of or within zymogen activation. Located in several cellular components, including dendrite; synaptic cleft; and terminal bouton. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and intellectual disability. Orthologous to human PRSS12 (serine protease 12). [provided by Alliance of Genome Resources, Apr 2022]

Prss12 Products(1)

mRNA	Protein	Name
NM_008939.2	NP_032965.1	neurotrypsin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables peptidase activity	IMP IMP: Inferred from mutant phenotype	17586728	MGI
enables serine-type endopeptidase activity	IDA IDA: Inferred from direct assay	17223089	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in exocytosis	IDA IDA: Inferred from direct assay	18272678	MGI
acts upstream of or within proteolysis	IDA IDA: Inferred from direct assay	17223089	MGI
acts upstream of or within proteolysis	IMP IMP: Inferred from mutant phenotype	17586728	MGI
acts upstream of or within zymogen activation	IDA IDA: Inferred from direct assay	17223089	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	18230682	MGI
located in axon	IDA IDA: Inferred from direct assay	18272678	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	17223089	MGI
located in dendrite	IDA IDA: Inferred from direct assay	17223089	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18230682	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	18272678	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	18230682	MGI
located in synapse	IDA IDA: Inferred from direct assay	18230682	MGI
located in synaptic cleft	IDA IDA: Inferred from direct assay	18272678	MGI
located in terminal bouton	IDA IDA: Inferred from direct assay	18272678	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neurotrypsin

brain-specific serine protease 3

serine protease 12

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11246	PRSS12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prss12	NCBI	NCBI:8492

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