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Dicer1 - dicer 1, ribonuclease type III Gene

Also Known as aviD; D12Ertd7e; mKIAA0928; 1110006F08Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 192119

Summary

Enables miRNA binding activity and ribonuclease III activity. Involved in several processes, including meiotic spindle organization; nervous system development; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; negative regulation of macromolecule metabolic process; and regulation of nervous system development. Located in cytoplasm. Part of RISC complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study DiGeorge syndrome and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; multinodular goiter; nephroma; and pleuropulmonary blastoma. Orthologous to human DICER1 (dicer 1, ribonuclease III). [provided by Alliance of Genome Resources, Apr 2022]

Dicer1 Products (2)

mRNA	Protein	Name
NM_001411829.1	NP_001398758.1	endoribonuclease Dicer isoform 1
NM_148948.2	NP_683750.2	endoribonuclease Dicer isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables miRNA binding	IDA IDA: Inferred from direct assay	18604195	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16938833	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within RNA processing	IDA IDA: Inferred from direct assay	14528307	MGI
acts upstream of or within RNA processing	IMP IMP: Inferred from mutant phenotype	17804764	MGI
acts upstream of or within anatomical structure development	IMP IMP: Inferred from mutant phenotype	22844247	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	15613470	MGI
acts upstream of or within branching morphogenesis of an epithelial tube	IMP IMP: Inferred from mutant phenotype	16452165	MGI
acts upstream of or within cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	18256189	MGI
acts upstream of or within cardiac neural crest cell development involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	21098571	MGI
acts upstream of or within cartilage development	IMP IMP: Inferred from mutant phenotype	21098571	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	20708584	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	18997113	MGI
acts upstream of or within defense response to virus	IMP IMP: Inferred from mutant phenotype	17613256	MGI
acts upstream of or within digestive tract development	IMP IMP: Inferred from mutant phenotype	21307095	MGI
acts upstream of or within embryonic hindlimb morphogenesis	IMP IMP: Inferred from mutant phenotype	16319892	MGI
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	16040801	MGI
acts upstream of or within epidermis morphogenesis	IMP IMP: Inferred from mutant phenotype	16682203	MGI
acts upstream of or within ganglion development	IMP IMP: Inferred from mutant phenotype	21098571	MGI
acts upstream of gene expression	IMP IMP: Inferred from mutant phenotype	16682203	MGI
acts upstream of or within hair follicle cell proliferation	IMP IMP: Inferred from mutant phenotype	16682203	MGI
acts upstream of or within hair follicle development	IMP IMP: Inferred from mutant phenotype	16682203	MGI
acts upstream of or within hair follicle morphogenesis	IMP IMP: Inferred from mutant phenotype	16682203	MGI
acts upstream of or within inner ear receptor cell development	IMP IMP: Inferred from mutant phenotype	19416898	MGI
acts upstream of or within intestinal epithelial cell development	IGI IGI: Inferred from genetic interaction	21307095	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	16452165	MGI
acts upstream of or within mRNA stabilization	IMP IMP: Inferred from mutant phenotype	22844247	MGI
involved in meiotic spindle organization	IMP IMP: Inferred from mutant phenotype	24209619	MGI
acts upstream of or within miRNA processing	IMP IMP: Inferred from mutant phenotype	15713842	MGI
involved in miRNA processing	IMP IMP: Inferred from mutant phenotype	20463238	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	16682203	MGI
acts upstream of or within myoblast differentiation involved in skeletal muscle regeneration	IMP IMP: Inferred from mutant phenotype	22358842	MGI
involved in negative regulation of Schwann cell proliferation	IMP IMP: Inferred from mutant phenotype	20805985	MGI
acts upstream of or within negative regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	20805985	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20463238	MGI
involved in nerve development	IMP IMP: Inferred from mutant phenotype	20463238	MGI
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	20463238	MGI
acts upstream of or within olfactory bulb interneuron differentiation	IMP IMP: Inferred from mutant phenotype	18184563	MGI
acts upstream of or within pericentric heterochromatin formation	IMP IMP: Inferred from mutant phenotype	15713842	MGI
involved in peripheral nervous system myelin formation	IMP IMP: Inferred from mutant phenotype	20463238	MGI
involved in positive regulation of Schwann cell differentiation	IMP IMP: Inferred from mutant phenotype	20463238	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16682203	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22053081	MGI
acts upstream of or within positive regulation of miRNA metabolic process	IMP IMP: Inferred from mutant phenotype	20975942	MGI
acts upstream of or within positive regulation of myelination	IMP IMP: Inferred from mutant phenotype	20805985	MGI
involved in positive regulation of myelination	IMP IMP: Inferred from mutant phenotype	20463238	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20805985	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	16682203	MGI
acts upstream of or within pre-miRNA processing	IDA IDA: Inferred from direct assay	18604195	MGI
acts upstream of or within regulation of RNA metabolic process	IMP IMP: Inferred from mutant phenotype	17613256	MGI
acts upstream of or within regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	20708584	MGI
acts upstream of or within regulation of enamel mineralization	IMP IMP: Inferred from mutant phenotype	20102707	MGI
acts upstream of or within regulation of epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	20102707	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20708584	MGI
acts upstream of or within regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	18725527	MGI
acts upstream of or within regulation of miRNA metabolic process	IMP IMP: Inferred from mutant phenotype	17613256	MGI
acts upstream of or within regulation of muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	22358842	MGI
acts upstream of or within regulation of myelination	IMP IMP: Inferred from mutant phenotype	20223197	MGI
acts upstream of or within regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	18184563	MGI
acts upstream of or within regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	17761882	MGI
acts upstream of or within regulation of odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	20102707	MGI
acts upstream of or within regulation of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	20223197	MGI
involved in regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	20805985	MGI
acts upstream of or within regulation of regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	18725527	MGI
acts upstream of or within regulation of stem cell differentiation	IMP IMP: Inferred from mutant phenotype	15713842	MGI
acts upstream of or within regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	17613256	MGI
acts upstream of or within regulatory ncRNA-mediated post-transcriptional gene silencing	IMP IMP: Inferred from mutant phenotype	15713842	MGI
acts upstream of or within reproductive structure development	IMP IMP: Inferred from mutant phenotype	22701646	MGI
acts upstream of or within siRNA processing	IDA IDA: Inferred from direct assay	14528307	MGI
involved in siRNA processing	IMP IMP: Inferred from mutant phenotype	24209619	MGI
acts upstream of or within spermatogonial cell division	IMP IMP: Inferred from mutant phenotype	18320056	MGI
acts upstream of or within spinal cord motor neuron differentiation	IMP IMP: Inferred from mutant phenotype	21338882	MGI
acts upstream of or within spindle assembly	IMP IMP: Inferred from mutant phenotype	17369397	MGI
acts upstream of or within spleen development	IMP IMP: Inferred from mutant phenotype	21307095	MGI
acts upstream of or within stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	14528307	MGI
acts upstream of or within trophectodermal cell proliferation	IMP IMP: Inferred from mutant phenotype	20708584	MGI
acts upstream of or within zygote asymmetric cell division	IMP IMP: Inferred from mutant phenotype	17369397	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of RISC complex	IDA IDA: Inferred from direct assay	22503104	MGI
part of RISC-loading complex	IPI IPI: Inferred from physical interaction	20211135	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	24209619	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16092937	MGI
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	16092937	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
endoribonuclease Dicer	Dicer1, Dcr-1 homolog double-strand-specific ribonuclease mDCR-1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03766	DICER1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dicer1	NCBI	NCBI:23405