Tmc2 - transmembrane channel-like gene family 2 Gene

Mus musculus

Also known as CWEA2

Gene ID: 192140 | Gene type: protein coding

About Tmc2

Summary

Enables mechanosensitive ion channel activity and voltage-gated Calcium Channel activity. Acts upstream of or within several processes, including calcium ion transmembrane transport; detection of mechanical stimulus involved in sensory perception of sound; and vestibular reflex. Located in stereocilium tip. Is expressed in inner ear. Orthologous to human TMC2 (transmembrane channel like 2). [provided by Alliance of Genome Resources, Apr 2022]

Tmc2 Products(1)

mRNA	Protein	Name
NM_138655.1	NP_619596.1	transmembrane channel-like protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel activity	IMP IMP: Inferred from mutant phenotype	23871232	MGI
enables mechanosensitive monoatomic ion channel activity	IGI IGI: Inferred from genetic interaction	24981230	MGI
enables mechanosensitive monoatomic ion channel activity	IMP IMP: Inferred from mutant phenotype	23871232	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	25114259	MGI
enables voltage-gated calcium channel activity	IGI IGI: Inferred from genetic interaction	23871232	MGI
enables voltage-gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	23871232	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within calcium ion transmembrane transport	IGI IGI: Inferred from genetic interaction	23871232	MGI
acts upstream of or within calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	23871232	MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound	IGI IGI: Inferred from genetic interaction	22105175	MGI
acts upstream of or within regulation of calcium ion transmembrane transport	IGI IGI: Inferred from genetic interaction	24981230	MGI
acts upstream of or within vestibular reflex	IGI IGI: Inferred from genetic interaction	22105175	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cuticular plate	IDA IDA: Inferred from direct assay	38228630	MGI
located in stereocilium	IDA IDA: Inferred from direct assay	38228630	MGI
located in stereocilium tip	IDA IDA: Inferred from direct assay	22105175	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transmembrane channel-like protein 2

transmembrane cochlear-expressed protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14622	TMC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tmc2	NCBI	NCBI:117532

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