Tmc2 - transmembrane channel-like gene family 2 Gene

Also Known as CWEA2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 192140

Summary

Enables mechanosensitive ion channel activity and voltage-gated Calcium Channel activity. Acts upstream of or within several processes, including calcium ion transmembrane transport; detection of mechanical stimulus involved in sensory perception of sound; and vestibular reflex. Located in stereocilium tip. Is expressed in inner ear. Orthologous to human TMC2 (transmembrane channel like 2). [provided by Alliance of Genome Resources, Apr 2022]

Tmc2 Products (1)

mRNA Protein Name
NM_138655.1 NP_619596.1 transmembrane channel-like protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium channel activity IMP
IMP: Inferred from mutant phenotype
23871232 MGI
enables mechanosensitive monoatomic ion channel activity IGI
IGI: Inferred from genetic interaction
24981230 MGI
enables mechanosensitive monoatomic ion channel activity IMP
IMP: Inferred from mutant phenotype
23871232 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
25114259 MGI
enables voltage-gated calcium channel activity IGI
IGI: Inferred from genetic interaction
23871232 MGI
enables voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
23871232 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium ion transmembrane transport IGI
IGI: Inferred from genetic interaction
23871232 MGI
acts upstream of or within calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
23871232 MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound IGI
IGI: Inferred from genetic interaction
22105175 MGI
acts upstream of or within regulation of calcium ion transmembrane transport IGI
IGI: Inferred from genetic interaction
24981230 MGI
acts upstream of or within vestibular reflex IGI
IGI: Inferred from genetic interaction
22105175 MGI
Cellular Component GO Annotation Evidence References Source
located in cuticular plate IDA
IDA: Inferred from direct assay
38228630 MGI
located in stereocilium IDA
IDA: Inferred from direct assay
38228630 MGI
located in stereocilium tip IDA
IDA: Inferred from direct assay
22105175 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transmembrane channel-like protein 2

  • transmembrane cochlear-expressed protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14622 TMC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tmc2 NCBI NCBI:117532