Edem1 - ER degradation enhancer, mannosidase alpha-like 1 Gene

Also Known as EDEM; mKIAA0212; A130059K23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 192193

Summary

Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Involved in positive regulation of retrograde protein transport, ER to cytosol and trimming of terminal mannose on C branch. Acts upstream of or within ubiquitin-dependent ERAD pathway. Is integral component of endoplasmic reticulum membrane. Is expressed in embryo and liver. Orthologous to human EDEM1 (ER degradation enhancing alpha-mannosidase like protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Edem1 Products (1)

mRNA Protein Name
NM_138677.2 NP_619618.1 ER degradation-enhancing alpha-mannosidase-like protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables alpha-mannosidase activity IDA
IDA: Inferred from direct assay
11375934 MGI
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IMP
IMP: Inferred from mutant phenotype
20065073 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21329881 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within ERAD pathway IDA
IDA: Inferred from direct assay
11375934 MGI
involved in positive regulation of retrograde protein transport, ER to cytosol IDA
IDA: Inferred from direct assay
24200403 MGI
involved in trimming of terminal mannose on C branch IMP
IMP: Inferred from mutant phenotype
20065073 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
11375934 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ER degradation-enhancing alpha-mannosidase-like protein 1

  • ER degradation ER degradation enhancer, mannosidase alpha-like 1

  • ER degradation-enhancing alpha-mannosidase-like 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-131986 LASSBio-1135 Antagonist 99.05% Unkown
HY-RS04157 EDEM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22478 Edem1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29001 Edem1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Edem1 NCBI NCBI:9695