Ptgr1 - prostaglandin reductase 1 Gene

Also Known as Dig1; Ltb4dh

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 192227

Summary

Enables 13-prostaglandin reductase activity and 2-alkenal reductase (NADP+) activity. Involved in response to antineoplastic agent. Predicted to be located in cytoplasm. Orthologous to human PTGR1 (prostaglandin reductase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ptgr1 Products (1)

mRNA Protein Name
NM_138863.2 NP_620218.1 prostaglandin reductase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
11524419 RGD
enables 2-alkenal reductase (NADPH) activity IDA
IDA: Inferred from direct assay
11524419 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular alkene metabolic process IDA
IDA: Inferred from direct assay
11524419 RGD
involved in leukotriene B4 metabolic process IDA
IDA: Inferred from direct assay
9667737 RGD
involved in negative regulation of positive chemotaxis IDA
IDA: Inferred from direct assay
9667737 RGD
involved in negative regulation of reactive oxygen species biosynthetic process IDA
IDA: Inferred from direct assay
9667737 RGD
involved in response to antineoplastic agent IEP
IEP: Inferred from expression pattern
8968041 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
24853774 RGD
located in cytosol IDA
IDA: Inferred from direct assay
9667737 RGD
located in nucleus IDA
IDA: Inferred from direct assay
24853774 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prostaglandin reductase 1

  • 15-oxoprostaglandin 13-reductase

  • D3T-inducible gene 1 protein

  • DIG-1

  • NAD(P)H-dependent alkenal/one oxidoreductase

  • NADP-dependent leukotriene B4 12-hydroxydehydrogenase

  • PRG-1

  • dithiolethione-inducible gene 1 protein

  • dithiolethione-inducible gene-1

  • le

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11390 PTGR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20089 Ptgr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26592 Ptgr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptgr1 NCBI NCBI:22949