Eif2b5 - eukaryotic translation initiation factor 2B subunit epsilon Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 192234

Summary

Enables translation initiation factor binding activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including hippocampus development; response to glucose; and response to lithium ion. Part of eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B5 (eukaryotic translation initiation factor 2B subunit epsilon). [provided by Alliance of Genome Resources, Apr 2022]

Eif2b5 Products (1)

mRNA Protein Name
NM_138866.2 NP_620221.2 translation initiation factor eIF-2B subunit epsilon

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
9582312 RGD
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
9139680 RGD
enables guanyl-nucleotide exchange factor activity IMP
IMP: Inferred from mutant phenotype
11500362 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11500362 RGD
enables translation initiation factor binding IDA
IDA: Inferred from direct assay
9446619 RGD
enables translation initiation factor binding IMP
IMP: Inferred from mutant phenotype
11500362 RGD
Biological Process GO Annotation Evidence References Source
involved in hippocampus development IEP
IEP: Inferred from expression pattern
12850562 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
11756553 RGD
involved in positive regulation of translation IDA
IDA: Inferred from direct assay
20484009 RGD
involved in response to glucose IDA
IDA: Inferred from direct assay
8567668 RGD
involved in response to heat IDA
IDA: Inferred from direct assay
9341116 RGD
involved in response to peptide hormone IDA
IDA: Inferred from direct assay
8430778 RGD
Cellular Component GO Annotation Evidence References Source
part of eukaryotic translation initiation factor 2B complex IDA
IDA: Inferred from direct assay
9139680 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

translation initiation factor eIF-2B subunit epsilon

  • eIF-2B GDP-GTP exchange factor subunit epsilon

  • eukaryotic translation initiation factor 2B subunit 5 epsilon

  • initiation factor eIF-2Be

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04252 EIF2B5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif2b5 NCBI NCBI:8893