Eif2b5 - eukaryotic translation initiation factor 2B subunit epsilon Gene

Rattus norvegicus

Gene ID: 192234 | Gene type: protein coding

About Eif2b5

Summary

Enables translation initiation factor binding activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including hippocampus development; response to glucose; and response to lithium ion. Part of eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B5 (eukaryotic translation initiation factor 2B subunit epsilon). [provided by Alliance of Genome Resources, Apr 2022]

Eif2b5 Products(1)

mRNA	Protein	Name
NM_138866.2	NP_620221.2	translation initiation factor eIF-2B subunit epsilon

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	9582312	RGD
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	9139680	RGD
enables guanyl-nucleotide exchange factor activity	IMP IMP: Inferred from mutant phenotype	11500362	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11500362	RGD
enables translation initiation factor binding	IDA IDA: Inferred from direct assay	9446619	RGD
enables translation initiation factor binding	IMP IMP: Inferred from mutant phenotype	11500362	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in hippocampus development	IEP IEP: Inferred from expression pattern	12850562	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	11756553	RGD
involved in positive regulation of translation	IDA IDA: Inferred from direct assay	20484009	RGD
involved in response to glucose	IDA IDA: Inferred from direct assay	8567668	RGD
involved in response to heat	IDA IDA: Inferred from direct assay	9341116	RGD
involved in response to peptide hormone	IDA IDA: Inferred from direct assay	8430778	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of eukaryotic translation initiation factor 2B complex	IDA IDA: Inferred from direct assay	9139680	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

translation initiation factor eIF-2B subunit epsilon

eIF-2B GDP-GTP exchange factor subunit epsilon	eukaryotic translation initiation factor 2B subunit 5 epsilon
initiation factor eIF-2Be

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04252	EIF2B5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eif2b5	NCBI	NCBI:8893

Name
Email *

	Sorry, but the email address you supplied was invalid.