Abcg4 - ATP binding cassette subfamily G member 4 Gene

Also Known as 6430517O04Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 192663

Summary

Enables ABC-type sterol transporter activity. Involved in Cholesterol efflux and Cholesterol homeostasis. Acts upstream of or within cellular response to Leukemia Inhibitory Factor. Located in endosome membrane. Is expressed in several structures, including alimentary system; immune system; liver; nervous system; and sensory organ. Orthologous to human ABCG4 (ATP binding cassette subfamily G member 4). [provided by Alliance of Genome Resources, Apr 2022]

Abcg4 Products (1)

mRNA	Protein	Name
NM_138955.3	NP_620405.3	ATP-binding cassette subfamily G member 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ABC-type sterol transporter activity	IMP IMP: Inferred from mutant phenotype	15210959	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to high density lipoprotein particle stimulus	IDA IDA: Inferred from direct assay	15210959	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
NOT involved in cholesterol efflux	IMP IMP: Inferred from mutant phenotype	16556852	MGI
involved in cholesterol efflux	IMP IMP: Inferred from mutant phenotype	15210959	MGI
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	17916878	MGI
involved in positive regulation of cholesterol biosynthetic process	IMP IMP: Inferred from mutant phenotype	17916878	MGI
involved in positive regulation of cholesterol efflux	IDA IDA: Inferred from direct assay	15210959	MGI
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17916878	MGI
involved in sterol transport	IMP IMP: Inferred from mutant phenotype	18039927	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	17916878	MGI
located in endosome	IDA IDA: Inferred from direct assay	17916878	MGI
located in endosome membrane	IDA IDA: Inferred from direct assay	17916878	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ATP-binding cassette subfamily G member 4 ATP-binding cassette sub-family G member 4	ATP-binding cassette transporter White2 ATP-binding cassette, sub-family G (WHITE), member 4

Protein Preferred Names

Protein Names

ATP-binding cassette subfamily G member 4

ATP-binding cassette sub-family G member 4

ATP-binding cassette transporter White2
ATP-binding cassette, sub-family G (WHITE), member 4

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00080	ABCG4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N12990	Myrigalone A	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abcg4	NCBI	NCBI:64137