Rab23 - RAB23, member RAS oncogene family Gene

Also Known as opb; opb2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19335

Summary

Predicted to enable GTPase activity. Involved in dorsal/ventral neural tube patterning. Acts upstream of or within several processes, including embryonic morphogenesis; regulation of smoothened signaling pathway; and spinal cord dorsal/ventral patterning. Located in endosome membrane and plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and genitourinary system. Human ortholog(s) of this gene implicated in Carpenter syndrome. Orthologous to human RAB23 (RAB23, member Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rab23 Products (2)

mRNA	Protein	Name
NM_001159729.1	NP_001153201.1	ras-related protein Rab-23
NM_008999.4	NP_033025.2	ras-related protein Rab-23

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in dorsal/ventral neural tube patterning	IMP IMP: Inferred from mutant phenotype	7720556	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	9636176	MGI
acts upstream of or within negative regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	16364285	MGI
acts upstream of or within nervous system development	IMP IMP: Inferred from mutant phenotype	11449277	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	9636176	MGI
involved in neural tube closure	IMP IMP: Inferred from mutant phenotype	7720556	MGI
acts upstream of proteolysis	IMP IMP: Inferred from mutant phenotype	16364285	MGI
acts upstream of or within regulation of smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	19004860	MGI
acts upstream of or within signal transduction	IMP IMP: Inferred from mutant phenotype	11449277	MGI
acts upstream of or within spinal cord dorsal/ventral patterning	IGI IGI: Inferred from genetic interaction	14603322	MGI
acts upstream of or within spinal cord dorsal/ventral patterning	IMP IMP: Inferred from mutant phenotype	15755804	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in endosome membrane	IDA IDA: Inferred from direct assay	16463280	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16463280	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ras-related protein Rab-23	open brain 2 protein open brain rab-15

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11533	RAB23 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rab23	NCBI	NCBI:51715