Rab3a - RAB3A, member RAS oncogene family Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19339

Summary

Enables GTP-dependent protein binding activity. Involved in several processes, including regulation of short-term neuronal synaptic plasticity; secretion by cell; and synaptic vesicle localization. Acts upstream of or within several processes, including chemical synaptic transmission; maintenance of presynaptic active zone structure; and synaptic vesicle maturation. Located in cytoplasmic vesicle; presynaptic active zone; and terminal bouton. Is anchored component of synaptic vesicle membrane. Is expressed in brain and inner ear. Orthologous to human RAB3A (RAB3A, member Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rab3a Products (5)

mRNA Protein Name
NM_001166399.3 NP_001159871.1 ras-related protein Rab-3A
NM_001328047.2 NP_001314976.1 ras-related protein Rab-3A
NM_001378892.1 NP_001365821.1 ras-related protein Rab-3A
NM_001378893.1 NP_001365822.1 ras-related protein Rab-3A
NM_009001.7 NP_033027.1 ras-related protein Rab-3A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTP-dependent protein binding IPI
IPI: Inferred from physical interaction
21262767 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11056535 MGI
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
11056535 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axonogenesis IMP
IMP: Inferred from mutant phenotype
11359932 MGI
involved in calcium-ion regulated exocytosis IMP
IMP: Inferred from mutant phenotype
20338242 MGI
involved in establishment of localization in cell IPI
IPI: Inferred from physical interaction
11056535 MGI
involved in evoked neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
9194562 MGI
involved in insulin secretion IPI
IPI: Inferred from physical interaction
11056535 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
11359932 MGI
acts upstream of or within maintenance of presynaptic active zone structure IMP
IMP: Inferred from mutant phenotype
11359932 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
11359932 MGI
acts upstream of or within neuromuscular synaptic transmission IMP
IMP: Inferred from mutant phenotype
11359932 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
11359932 MGI
acts upstream of or within regulation of exocytosis IDA
IDA: Inferred from direct assay
12167638 MGI
involved in regulation of presynaptic dense core granule exocytosis IDA
IDA: Inferred from direct assay
31679900 MGI
involved in regulation of presynaptic dense core granule exocytosis IEP
IEP: Inferred from expression pattern
31679900 MGI
involved in regulation of presynaptic dense core granule exocytosis IMP
IMP: Inferred from mutant phenotype
31679900 MGI
involved in regulation of short-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
9194562 MGI
involved in regulation of synaptic vesicle fusion to presynaptic active zone membrane IDA
IDA: Inferred from direct assay
9194562 MGI
acts upstream of or within regulation of synaptic vesicle fusion to presynaptic active zone membrane IMP
IMP: Inferred from mutant phenotype
11359932 MGI
involved in regulation of synaptic vesicle fusion to presynaptic active zone membrane IMP
IMP: Inferred from mutant phenotype
9194562 MGI
acts upstream of or within respiratory system process IMP
IMP: Inferred from mutant phenotype
11359932 MGI
acts upstream of or within response to electrical stimulus IMP
IMP: Inferred from mutant phenotype
11359932 MGI
acts upstream of or within sensory perception of touch IMP
IMP: Inferred from mutant phenotype
11359932 MGI
involved in synaptic vesicle clustering IMP
IMP: Inferred from mutant phenotype
20338242 MGI
acts upstream of or within synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
11359932 MGI
acts upstream of or within synaptic vesicle maturation IMP
IMP: Inferred from mutant phenotype
11359932 MGI
involved in synaptic vesicle transport IDA
IDA: Inferred from direct assay
11598194 MGI
Cellular Component GO Annotation Evidence References Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
21128978 MGI
located in endosome IDA
IDA: Inferred from direct assay
11182090 MGI
located in postsynapse IDA
IDA: Inferred from direct assay
31651360 MGI
located in presynapse IDA
IDA: Inferred from direct assay
31651360 MGI
located in presynaptic active zone IDA
IDA: Inferred from direct assay
18448650 MGI
located in synaptic vesicle IDA
IDA: Inferred from direct assay
12167638 MGI
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
12167638 MGI
is active in synaptic vesicle membrane IEP
IEP: Inferred from expression pattern
12167638 MGI
located in terminal bouton IDA
IDA: Inferred from direct assay
16782817 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ras-related protein Rab-3A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11555 RAB3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rab3a NCBI NCBI:5864