Rab3a - RAB3A, member RAS oncogene family Gene

Mus musculus

Gene ID: 19339 | Gene type: protein coding

About Rab3a

Summary

Enables GTP-dependent protein binding activity. Involved in several processes, including regulation of short-term neuronal synaptic plasticity; secretion by cell; and synaptic vesicle localization. Acts upstream of or within several processes, including chemical synaptic transmission; maintenance of presynaptic active zone structure; and synaptic vesicle maturation. Located in cytoplasmic vesicle; presynaptic active zone; and terminal bouton. Is anchored component of synaptic vesicle membrane. Is expressed in brain and inner ear. Orthologous to human RAB3A (RAB3A, member Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rab3a Products(5)

mRNA	Protein	Name
NM_001166399.3	NP_001159871.1	ras-related protein Rab-3A
NM_001328047.2	NP_001314976.1	ras-related protein Rab-3A
NM_001378892.1	NP_001365821.1	ras-related protein Rab-3A
NM_001378893.1	NP_001365822.1	ras-related protein Rab-3A
NM_009001.7	NP_033027.1	ras-related protein Rab-3A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP-dependent protein binding	IPI IPI: Inferred from physical interaction	21262767	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11056535	MGI
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	11056535	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axonogenesis	IMP IMP: Inferred from mutant phenotype	11359932	MGI
involved in calcium-ion regulated exocytosis	IMP IMP: Inferred from mutant phenotype	20338242	MGI
involved in establishment of localization in cell	IPI IPI: Inferred from physical interaction	11056535	MGI
involved in evoked neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	9194562	MGI
involved in insulin secretion	IPI IPI: Inferred from physical interaction	11056535	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	11359932	MGI
acts upstream of or within maintenance of presynaptic active zone structure	IMP IMP: Inferred from mutant phenotype	11359932	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	11359932	MGI
acts upstream of or within neuromuscular synaptic transmission	IMP IMP: Inferred from mutant phenotype	11359932	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	11359932	MGI
acts upstream of or within regulation of exocytosis	IDA IDA: Inferred from direct assay	12167638	MGI
involved in regulation of presynaptic dense core granule exocytosis	IDA IDA: Inferred from direct assay	31679900	MGI
involved in regulation of presynaptic dense core granule exocytosis	IEP IEP: Inferred from expression pattern	31679900	MGI
involved in regulation of presynaptic dense core granule exocytosis	IMP IMP: Inferred from mutant phenotype	31679900	MGI
involved in regulation of short-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	9194562	MGI
involved in regulation of synaptic vesicle fusion to presynaptic active zone membrane	IDA IDA: Inferred from direct assay	9194562	MGI
acts upstream of or within regulation of synaptic vesicle fusion to presynaptic active zone membrane	IMP IMP: Inferred from mutant phenotype	11359932	MGI
involved in regulation of synaptic vesicle fusion to presynaptic active zone membrane	IMP IMP: Inferred from mutant phenotype	9194562	MGI
acts upstream of or within respiratory system process	IMP IMP: Inferred from mutant phenotype	11359932	MGI
acts upstream of or within response to electrical stimulus	IMP IMP: Inferred from mutant phenotype	11359932	MGI
acts upstream of or within sensory perception of touch	IMP IMP: Inferred from mutant phenotype	11359932	MGI
involved in synaptic vesicle clustering	IMP IMP: Inferred from mutant phenotype	20338242	MGI
acts upstream of or within synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	11359932	MGI
acts upstream of or within synaptic vesicle maturation	IMP IMP: Inferred from mutant phenotype	11359932	MGI
involved in synaptic vesicle transport	IDA IDA: Inferred from direct assay	11598194	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	21128978	MGI
located in endosome	IDA IDA: Inferred from direct assay	11182090	MGI
located in postsynapse	IDA IDA: Inferred from direct assay	31651360	MGI
located in presynapse	IDA IDA: Inferred from direct assay	31651360	MGI
located in presynaptic active zone	IDA IDA: Inferred from direct assay	18448650	MGI
located in synaptic vesicle	IDA IDA: Inferred from direct assay	12167638	MGI
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	12167638	MGI
is active in synaptic vesicle membrane	IEP IEP: Inferred from expression pattern	12167638	MGI
located in terminal bouton	IDA IDA: Inferred from direct assay	16782817	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ras-related protein Rab-3A

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11555	RAB3A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rab3a	NCBI	NCBI:5864

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