Rab4a - RAB4A, member RAS oncogene family Gene

Mus musculus

Also known as Rab4

Gene ID: 19341 | Gene type: protein coding

About Rab4a

Summary

Predicted to enable several functions, including ATPase binding activity; guanyl ribonucleotide binding activity; and ionotropic glutamate receptor binding activity. Acts upstream of or within protein transport; regulation of endocytosis; and small GTPase mediated signal transduction. Located in endosome. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and liver and biliary system. Orthologous to human RAB4A (RAB4A, member Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rab4a Products(1)

mRNA	Protein	Name
NM_009003.4	NP_033029.2	ras-related protein Rab-4A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11172003	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in neurotransmitter receptor transport postsynaptic membrane to endosome	IDA IDA: Inferred from direct assay	24217640	MGI
involved in neurotransmitter receptor transport postsynaptic membrane to endosome	IMP IMP: Inferred from mutant phenotype	24217640	MGI
acts upstream of or within protein transport	IDA IDA: Inferred from direct assay	11172003	MGI
acts upstream of or within regulation of endocytosis	IDA IDA: Inferred from direct assay	11172003	MGI
acts upstream of or within small GTPase-mediated signal transduction	IDA IDA: Inferred from direct assay	11172003	MGI
involved in vesicle-mediated transport in synapse	IDA IDA: Inferred from direct assay	24217640	MGI
involved in vesicle-mediated transport in synapse	IMP IMP: Inferred from mutant phenotype	24217640	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18656450	MGI
located in endosome	IDA IDA: Inferred from direct assay	11172003	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	24217640	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	24217640	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ras-related protein Rab-4A

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11569	RAB4A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rab4a	NCBI	NCBI:5867

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