Rapsn - receptor-associated protein of the synapse Gene

Also Known as Raps; 43kDa; Nraps; rapsyn

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19400

Summary

Enables acetylcholine receptor binding activity. Acts upstream of or within positive regulation of neuron apoptotic process. Located in Golgi apparatus; neuromuscular junction; and plasma membrane. Is active in postsynaptic specialization membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; forelimb bud; limb; and skeletal musculature. Used to study congenital myasthenic syndrome 11. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 11 and fetal akinesia deformation sequence syndrome 2. Orthologous to human RAPSN (receptor associated protein of the synapse). [provided by Alliance of Genome Resources, Apr 2022]

Rapsn Products (1)

mRNA Protein Name
NM_009023.3 NP_033049.2 43 kDa receptor-associated protein of the synapse

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acetylcholine receptor binding IPI
IPI: Inferred from physical interaction
18420419 MGI
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
18420419 MGI
enables structural constituent of postsynaptic specialization IDA
IDA: Inferred from direct assay
27839998 MGI
enables structural constituent of postsynaptic specialization IMP
IMP: Inferred from mutant phenotype
27839998 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of motor neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
11312299 MGI
involved in neuromuscular junction development IMP
IMP: Inferred from mutant phenotype
8653787 MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
27839998 MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
8653787 MGI
acts upstream of or within positive regulation of motor neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
11312299 MGI
involved in skeletal muscle acetylcholine-gated channel clustering IDA
IDA: Inferred from direct assay
18420419 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
12388596 MGI
located in membrane IDA
IDA: Inferred from direct assay
20053883 MGI
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
9136771 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
8416841 MGI
is active in neuromuscular junction IMP
IMP: Inferred from mutant phenotype
27225759 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12388596 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
14622576 MGI
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
9136771 MGI
is active in postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
27225759 MGI
located in synapse IDA
IDA: Inferred from direct assay
20053883 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

43 kDa receptor-associated protein of the synapse

  • 43 kDa postsynaptic protein

  • 43kDa acetylcholine receptor-associated protein

  • acetylcholine receptor-associated 43 kDa protein

  • receptor-associated protein of the synapse, 43 kDa

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11668 RAPSN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rapsn NCBI NCBI:5913