Grhl1 - grainyhead like transcription factor 1 Gene

Also Known as MGR; LBP-32; Tcfcp2l2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 195733

Summary

Enables transcription cis-regulatory region binding activity. Involved in epidermis development. Acts upstream of or within desmosome organization; establishment of skin barrier; and regulation of keratinocyte differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Orthologous to human GRHL1 (grainyhead like transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Grhl1 Products (2)

mRNA Protein Name
NM_001161406.1 NP_001154878.1 grainyhead-like protein 1 homolog isoform 1
NM_145890.2 NP_665897.2 grainyhead-like protein 1 homolog isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18288204 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
18288204 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within desmosome organization IMP
IMP: Inferred from mutant phenotype
24586629 MGI
involved in epidermis development IDA
IDA: Inferred from direct assay
18288204 MGI
involved in epidermis development IMP
IMP: Inferred from mutant phenotype
21081122 MGI
acts upstream of or within establishment of skin barrier IMP
IMP: Inferred from mutant phenotype
24586629 MGI
acts upstream of or within regulation of keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
24586629 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
18288204 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

grainyhead-like protein 1 homolog

  • grainyhead like 1

  • grainyhead-like 1

  • mammalian grainyhead

  • p61 MGR

  • p70 MGR

  • transcription factor CP2-like 2

  • transcription factor LBP-32

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05787 GRHL1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grhl1 NCBI NCBI:29841