Grhl1 - grainyhead like transcription factor 1 Gene

Mus musculus

Also known as MGR; LBP-32; Tcfcp2l2

Gene ID: 195733 | Gene type: protein coding

About Grhl1

Summary

Enables transcription cis-regulatory region binding activity. Involved in epidermis development. Acts upstream of or within desmosome organization; establishment of skin barrier; and regulation of keratinocyte differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Orthologous to human GRHL1 (grainyhead like transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Grhl1 Products(2)

mRNA	Protein	Name
NM_001161406.1	NP_001154878.1	grainyhead-like protein 1 homolog isoform 1
NM_145890.2	NP_665897.2	grainyhead-like protein 1 homolog isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18288204	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18288204	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within desmosome organization	IMP IMP: Inferred from mutant phenotype	24586629	MGI
involved in epidermis development	IDA IDA: Inferred from direct assay	18288204	MGI
involved in epidermis development	IMP IMP: Inferred from mutant phenotype	21081122	MGI
acts upstream of or within establishment of skin barrier	IMP IMP: Inferred from mutant phenotype	24586629	MGI
acts upstream of or within regulation of keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	24586629	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	18288204	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

grainyhead-like protein 1 homolog

grainyhead like 1	grainyhead-like 1
mammalian grainyhead	p61 MGR
p70 MGR	transcription factor CP2-like 2
transcription factor LBP-32

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05787	GRHL1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grhl1	NCBI	NCBI:29841

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