PAOX - polyamine oxidase Gene

Homo sapiens

Also known as PAO

Gene ID: 196743 | Gene type: protein coding

About PAOX

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:133,379,262-133,391,694 (from NCBI)

This gene has 10 transcripts (splice variants), 236 orthologues and 7 paralogues. Broad expression in testis (RPKM 17.7), spleen (RPKM 4.1) and 20 other tissues.

Summary

Enables polyamine oxidase activity. Involved in polyamine metabolic process and positive regulation of spermidine biosynthetic process. Predicted to be located in cytosol and peroxisomal matrix. [provided by Alliance of Genome Resources, Apr 2022]

PAOX Products(3)

mRNA	Protein	Name
NM_152911.4	NP_690875.1	peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform 1
NM_207127.3	NP_997010.1	peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform 2
NM_207128.3	NP_997011.1	peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform 4

PAOX Protein Structure

Amino_oxidase

0
100
200
300
400
511 a.a.

Protein Preferred Names

Protein Names

peroxisomal N(1)-acetyl-spermine/spermidine oxidase

peroxisomal N1-acetyl-spermine/spermidine oxidase

Related Diseases

Diseases

Alias

Syndromic X-Linked Intellectual Disability Snyder Type

Snyder-Robinson Syndrome	Mental Retardation, X-Linked, Snyder-Robinson Type
Spermine Synthase Deficiency	Srs
Snyder-Robinson Mental Retardation Syndrome	X-Linked Intellectual Disability Snyder-Robinson Type
Mental Retardation, X-Linked, Syndromic, Snyder-Robinson Type	Snyder-Robinson X-Linked Mental Retardation Syndrome

Keratosis Follicularis Spinulosa Decalvans

Kfsd	Keratosis Follicularis Spinulosa Decalvans Cum Ophiasi
Keratosis Follicularis Spinulosa Decalvans, X-Linked	Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant

Keratosis Pilaris Atrophicans

KPA	Burnett Schwartz Berberian Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10024	PAOX Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PAOX	MGD	MGI:1916983
Bos taurus	PAOX	VGNC	VGNC:32570
Rattus norvegicus	PAOX	RGD	RGD:1561125