PAOX - polyamine oxidase Gene

Also Known as PAO

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 196743

About PAOX

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:133,379,262-133,391,694 (from NCBI)

This gene has 10 transcripts (splice variants), 236 orthologues and 7 paralogues. Broad expression in testis (RPKM 17.7), spleen (RPKM 4.1) and 20 other tissues.

Summary

Enables polyamine oxidase activity. Involved in polyamine metabolic process and positive regulation of spermidine biosynthetic process. Predicted to be located in cytosol and peroxisomal matrix. [provided by Alliance of Genome Resources, Apr 2022]

PAOX Products (3)

mRNA Protein Name
NM_152911.4 NP_690875.1 peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform 1
NM_207127.3 NP_997010.1 peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform 2
NM_207128.3 NP_997011.1 peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables polyamine oxidase activity IDA
IDA: Inferred from direct assay
12477380 GOA
Biological Process GO Annotation Evidence References Source
involved in polyamine catabolic process IDA
IDA: Inferred from direct assay
12477380 GOA
involved in positive regulation of spermidine biosynthetic process IDA
IDA: Inferred from direct assay
16354669 GOA
involved in putrescine biosynthetic process IDA
IDA: Inferred from direct assay
16354669 GOA
involved in putrescine catabolic process IDA
IDA: Inferred from direct assay
16354669 GOA
involved in spermidine catabolic process IDA
IDA: Inferred from direct assay
16354669 GOA
involved in spermine catabolic process IDA
IDA: Inferred from direct assay
16354669 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAOX Protein Structure

Amino_oxidase

Amino_oxidase: Flavin containing amine oxidoreductase (23 - 497)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 511 a.a.
Protein Preferred Names Protein Names

peroxisomal N(1)-acetyl-spermine/spermidine oxidase

  • peroxisomal N1-acetyl-spermine/spermidine oxidase

Related Diseases

Diseases Alias
Syndromic X-Linked Intellectual Disability Snyder Type

  • Snyder-Robinson Syndrome

  • Mental Retardation, X-Linked, Snyder-Robinson Type

  • Spermine Synthase Deficiency

  • Srs

  • Snyder-Robinson Mental Retardation Syndrome

  • X-Linked Intellectual Disability Snyder-Robinson Type

  • Mental Retardation, X-Linked, Syndromic, Snyder-Robinson Type

  • Snyder-Robinson X-Linked Mental Retardation Syndrome
Keratosis Follicularis Spinulosa Decalvans

  • Kfsd

  • Keratosis Follicularis Spinulosa Decalvans Cum Ophiasi

  • Keratosis Follicularis Spinulosa Decalvans, X-Linked

  • Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant
Keratosis Pilaris Atrophicans

  • KPA

  • Burnett Schwartz Berberian Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS17057 Acox1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10024 PAOX Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PAOX MGD MGI:1916983
Bos taurus PAOX VGNC VGNC:32570
Rattus norvegicus PAOX RGD RGD:1561125
Others PAOX NCBI