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Reln - reelin Gene

Also Known as rl; reeler

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19699

Summary

Enables very-low-density lipoprotein particle receptor binding activity. Involved in several processes, including positive regulation of cell communication; postsynaptic membrane organization; and regulation of neurotransmitter receptor activity. Acts upstream of or within several processes, including nervous system development; peptidyl-tyrosine phosphorylation; and thyroid hormone metabolic process. Located in several cellular components, including dendrite; extracellular matrix; and extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in Norman-Roberts syndrome; autistic disorder; and familial temporal lobe epilepsy 7. Orthologous to human RELN (reelin). [provided by Alliance of Genome Resources, Apr 2022]

Reln Products (2)

mRNA	Protein	Name
NM_001310464.1	NP_001297393.1	reelin isoform 2 precursor
NM_011261.2	NP_035391.2	reelin isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables lipoprotein particle receptor binding	IPI IPI: Inferred from physical interaction	10571240	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10571241	MGI
enables receptor ligand activity	IDA IDA: Inferred from direct assay	10571241	MGI
enables serine-type peptidase activity	IDA IDA: Inferred from direct assay	11689558	MGI
enables very-low-density lipoprotein particle receptor binding	IPI IPI: Inferred from physical interaction	10571240	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in NMDA glutamate receptor clustering	IMP IMP: Inferred from mutant phenotype	21664258	MGI
involved in associative learning	IDA IDA: Inferred from direct assay	21852430	MGI
involved in associative learning	IMP IMP: Inferred from mutant phenotype	21852430	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	16324103	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	12223565	MGI
acts upstream of or within cell migration	IMP IMP: Inferred from mutant phenotype	17694053	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	12925587	MGI
acts upstream of or within central nervous system development	IMP IMP: Inferred from mutant phenotype	11900467	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	21491433	MGI
acts upstream of or within cerebral cortex tangential migration	IMP IMP: Inferred from mutant phenotype	16901480	MGI
acts upstream of or within dendrite development	IGI IGI: Inferred from genetic interaction	14715136	MGI
acts upstream of or within dendrite development	IMP IMP: Inferred from mutant phenotype	14715136	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	17694053	MGI
acts upstream of or within glial cell differentiation	IMP IMP: Inferred from mutant phenotype	12925587	MGI
involved in hippocampus development	IDA IDA: Inferred from direct assay	17229826	MGI
acts upstream of or within interneuron migration	IMP IMP: Inferred from mutant phenotype	14980731	MGI
involved in lateral motor column neuron migration	IMP IMP: Inferred from mutant phenotype	20711475	MGI
involved in layer formation in cerebral cortex	IDA IDA: Inferred from direct assay	10880573	MGI
acts upstream of or within layer formation in cerebral cortex	IMP IMP: Inferred from mutant phenotype	20847152	MGI
involved in learning	IMP IMP: Inferred from mutant phenotype	21852430	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	24539699	MGI
involved in long-term memory	IDA IDA: Inferred from direct assay	21852430	MGI
involved in long-term memory	IMP IMP: Inferred from mutant phenotype	21852430	MGI
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	21852430	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	18778775	MGI
acts upstream of or within motor neuron migration	IMP IMP: Inferred from mutant phenotype	15703280	MGI
acts upstream of or within neuron migration	IGI IGI: Inferred from genetic interaction	11226314	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	12223565	MGI
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	12526740	MGI
involved in positive regulation of AMPA receptor activity	IMP IMP: Inferred from mutant phenotype	17229826	MGI
involved in positive regulation of CREB transcription factor activity	IMP IMP: Inferred from mutant phenotype	21852430	MGI
involved in positive regulation of TOR signaling	IDA IDA: Inferred from direct assay	21664258	MGI
involved in positive regulation of dendritic spine morphogenesis	IDA IDA: Inferred from direct assay	21852430	MGI
involved in positive regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	21664258	MGI
involved in positive regulation of excitatory postsynaptic potential	IDA IDA: Inferred from direct assay	17229826	MGI
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	17229826	MGI
involved in positive regulation of lateral motor column neuron migration	IMP IMP: Inferred from mutant phenotype	20711475	MGI
involved in positive regulation of long-term synaptic potentiation	IDA IDA: Inferred from direct assay	21852430	MGI
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17229826	MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	10571240	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	21664258	MGI
acts upstream of or within positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	12526740	MGI
acts upstream of or within positive regulation of protein kinase activity	IGI IGI: Inferred from genetic interaction	12526740	MGI
involved in positive regulation of protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	21852430	MGI
acts upstream of or within positive regulation of small GTPase mediated signal transduction	IDA IDA: Inferred from direct assay	15062102	MGI
involved in positive regulation of synapse maturation	IDA IDA: Inferred from direct assay	17229826	MGI
involved in positive regulation of synapse maturation	IMP IMP: Inferred from mutant phenotype	17229826	MGI
involved in positive regulation of synaptic transmission, glutamatergic	IDA IDA: Inferred from direct assay	17229826	MGI
involved in positive regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	17229826	MGI
involved in postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	21664258	MGI
involved in postsynaptic density protein 95 clustering	IMP IMP: Inferred from mutant phenotype	21664258	MGI
involved in protein localization to synapse	IMP IMP: Inferred from mutant phenotype	21664258	MGI
involved in receptor localization to synapse	IMP IMP: Inferred from mutant phenotype	21664258	MGI
involved in reelin-mediated signaling pathway	IDA IDA: Inferred from direct assay	10571240	MGI
involved in regulation of NMDA receptor activity	IMP IMP: Inferred from mutant phenotype	20357114	MGI
involved in regulation of behavior	IMP IMP: Inferred from mutant phenotype	20357114	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	15255972	MGI
involved in regulation of synapse maturation	IDA IDA: Inferred from direct assay	27624722	MGI
involved in regulation of synapse maturation	IMP IMP: Inferred from mutant phenotype	27624722	MGI
acts upstream of or within response to pain	IMP IMP: Inferred from mutant phenotype	16580148	MGI
acts upstream of or within spinal cord patterning	IMP IMP: Inferred from mutant phenotype	16580148	MGI
involved in ventral spinal cord development	IEP IEP: Inferred from expression pattern	20711475	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15525772	MGI
located in dendrite	IDA IDA: Inferred from direct assay	15677725	MGI
located in extracellular matrix	IDA IDA: Inferred from direct assay	22665518	MGI
is active in extracellular space	IDA IDA: Inferred from direct assay	8987733	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	10939329	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
reelin	extracellular matrix serine protease

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11835	RELN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18151	Reln Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24626	Reln Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Reln	NCBI	NCBI:5649