Rfxank - regulatory factor X-associated ankyrin-containing protein Gene

Mus musculus

Also known as Tvl1

Gene ID: 19727 | Gene type: protein coding

About Rfxank

Summary

Enables histone deacetylase binding activity. Acts upstream of or within Ras protein signal transduction and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in central nervous system; genitourinary system; and retina. Human ortholog(s) of this gene implicated in MHC class II deficiency and severe combined immunodeficiency. Orthologous to human RFXANK (regulatory factor X associated ankyrin containing protein). [provided by Alliance of Genome Resources, Apr 2022]

Rfxank Products(2)

mRNA	Protein	Name
NM_001025589.1	NP_001020760.1	DNA-binding protein RFXANK isoform 2
NM_011266.2	NP_035396.1	DNA-binding protein RFXANK isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone deacetylase binding	IDA IDA: Inferred from direct assay	16236793	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16236793	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Ras protein signal transduction	IPI IPI: Inferred from physical interaction	10329666	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16236793	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10329666	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10329666	MGI
located in nucleus	IGI IGI: Inferred from genetic interaction	16236793	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

DNA-binding protein RFXANK

RFX-B	ankyrin repeat-containing adapter protein Tvl-1
regulatory factor X subunit B

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11887	RFXANK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rfxank	NCBI	NCBI:8625

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