Rfxank - regulatory factor X-associated ankyrin-containing protein Gene

Also Known as Tvl1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19727

Summary

Enables histone deacetylase binding activity. Acts upstream of or within Ras protein signal transduction and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in central nervous system; genitourinary system; and retina. Human ortholog(s) of this gene implicated in MHC class II deficiency and severe combined immunodeficiency. Orthologous to human RFXANK (regulatory factor X associated ankyrin containing protein). [provided by Alliance of Genome Resources, Apr 2022]

Rfxank Products (2)

mRNA Protein Name
NM_001025589.1 NP_001020760.1 DNA-binding protein RFXANK isoform 2
NM_011266.2 NP_035396.1 DNA-binding protein RFXANK isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone deacetylase binding IDA
IDA: Inferred from direct assay
16236793 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16236793 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Ras protein signal transduction IPI
IPI: Inferred from physical interaction
10329666 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16236793 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10329666 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10329666 MGI
located in nucleus IGI
IGI: Inferred from genetic interaction
16236793 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA-binding protein RFXANK

  • RFX-B

  • ankyrin repeat-containing adapter protein Tvl-1

  • regulatory factor X subunit B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11887 RFXANK Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rfxank NCBI NCBI:8625