Rit1 - Ras-like without CAAX 1 Gene

Also Known as Rit; RIBB; ROC1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19769

Summary

Enables GTP binding activity. Predicted to be involved in Ras protein signal transduction. Located in plasma membrane. Is expressed in Meckel's cartilage; bone; hip; and rib. Used to study Noonan syndrome 8. Human ortholog(s) of this gene implicated in Noonan syndrome 8. Orthologous to human RIT1 (Ras like without CAAX 1). [provided by Alliance of Genome Resources, Apr 2022]

Rit1 Products (11)

mRNA Protein Name
NM_001163310.2 NP_001156782.1 GTP-binding protein Rit1 isoform 2
NM_001404021.1 NP_001390950.1 GTP-binding protein Rit1 isoform 1
NM_001404022.1 NP_001390951.1 GTP-binding protein Rit1 isoform 1
NM_001404029.1 NP_001390958.1 GTP-binding protein Rit1 isoform 2
NM_001404030.1 NP_001390959.1 GTP-binding protein Rit1 isoform 2
NM_001404031.1 NP_001390960.1 GTP-binding protein Rit1 isoform 2
NM_001404033.1 NP_001390962.1 GTP-binding protein Rit1 isoform 3
NM_001404034.1 NP_001390963.1 GTP-binding protein Rit1 isoform 3
NM_001404035.1 NP_001390964.1 GTP-binding protein Rit1 isoform 4
NM_001404036.1 NP_001390965.1 GTP-binding protein Rit1 isoform 3
NM_009069.5 NP_033095.1 GTP-binding protein Rit1 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTP binding IDA
IDA: Inferred from direct assay
8824319 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10869344 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
8824319 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GTP-binding protein Rit1

  • RAS-like protein expressed in many tissues

  • ras-like without CAAX protein 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-144903 Migoprotafib Inhibitor 98.81% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01414 BCL11B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12003 RIT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21827 Bcl11b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rit1 NCBI NCBI:6016