Rnaseh1 - ribonuclease H1 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19819

Summary

This gene encodes an Endonuclease that specifically degrades the RNA of RNA-DNA hybrids and is necessary for DNA replication and repair. This enzyme is present in both mitochondria and nuclei, which are resulted from translation of a single mRNA with two in-frame initiation start codons. The use of the first start codon produces the mitochondrial isoform and the use of the second start codon produces the nuclear isoform. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF) which encodes 7aa in mouse. An alternately spliced transcript variant has been found which is a candidate for nonsense-mediated mRNA decay (NMD). [provided by RefSeq, Nov 2013]

Rnaseh1 Products (4)

mRNA Protein Name
NM_001286865.1 NP_001273794.1 ribonuclease H1 isoform 2
NM_011275.3 NP_035405.2 ribonuclease H1 isoform 1 precursor
NM_001286865.1 NP_001273794.1 ribonuclease H1 isoform 2
NM_011275.3 NP_035405.2 ribonuclease H1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA-DNA hybrid ribonuclease activity IDA
IDA: Inferred from direct assay
15831789 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
15831789 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within mitochondrial DNA replication IMP
IMP: Inferred from mutant phenotype
12667461 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
12667461 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12667461 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ribonuclease H1

  • RNase H1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12024 RNASEH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rnaseh1 NCBI NCBI:246243