Rnf7 - ring finger protein 7 Gene

Also Known as SAG; Rbx2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19823

Summary

Predicted to enable NEDD8 Ligase activity; cullin family protein binding activity; and ubiquitin protein Ligase activity. Acts upstream of or within several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; brain development; and intrinsic apoptotic signaling pathway in response to oxidative stress. Located in cytoplasm and nucleus. Is expressed in brain; eye; and genitourinary system. Orthologous to human RNF7 (ring finger protein 7). [provided by Alliance of Genome Resources, Apr 2022]

Rnf7 Products (2)

mRNA	Protein	Name
NM_001311135.1	NP_001298064.1	RING-box protein 2 isoform 2
NM_011279.3	NP_035409.1	RING-box protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15601820	MGI
enables ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	24210661	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	10082581	MGI
acts upstream of or within apoptotic mitochondrial changes	IDA IDA: Inferred from direct assay	10082581	MGI
acts upstream of or within cerebral cortex radially oriented cell migration	IGI IGI: Inferred from genetic interaction	24210661	MGI
acts upstream of or within cerebral cortex radially oriented cell migration	IMP IMP: Inferred from mutant phenotype	24210661	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress	IDA IDA: Inferred from direct assay	10082581	MGI
acts upstream of or within negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	10082581	MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	24210661	MGI
acts upstream of or within radial glia guided migration of Purkinje cell	IGI IGI: Inferred from genetic interaction	24210661	MGI
acts upstream of or within radial glia guided migration of Purkinje cell	IMP IMP: Inferred from mutant phenotype	24210661	MGI
acts upstream of negative effect reelin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	24210661	MGI
involved in regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	24210661	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of Cul5-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	24210661	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10082581	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10082581	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
RING-box protein 2	sensitive to apoptosis gene protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12096	RNF7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rnf7	NCBI	NCBI:9616