ARHGAP27 - Rho GTPase activating protein 27 Gene

Homo sapiens

Also known as PP905; SH3D20; SH3P20; CAMGAP1

Gene ID: 201176 | Gene type: protein coding

About ARHGAP27

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:45,393,908-45,432,870 (from NCBI)

This gene has 24 transcripts (splice variants), 1 gene allele, 276 orthologues and 3 paralogues. Ubiquitous expression in esophagus (RPKM 12.5), spleen (RPKM 12.5) and 23 other tissues.

Summary

This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013]

ARHGAP27 Products(19)

mRNA	Protein	Name
NM_001282290.2	NP_001269219.1	rho GTPase-activating protein 27 isoform d
NM_001385384.1	NP_001372313.1	rho GTPase-activating protein 27 isoform e
NM_001385385.1	NP_001372314.1	rho GTPase-activating protein 27 isoform f
NM_001385386.1	NP_001372315.1	rho GTPase-activating protein 27 isoform g
NM_001385387.1	NP_001372316.1	rho GTPase-activating protein 27 isoform h
NM_001385388.1	NP_001372317.1	rho GTPase-activating protein 27 isoform i
NM_001385389.1	NP_001372318.1	rho GTPase-activating protein 27 isoform j
NM_001385390.1	NP_001372319.1	rho GTPase-activating protein 27 isoform k
NM_001385391.1	NP_001372320.1	rho GTPase-activating protein 27 isoform l
NM_001385392.1	NP_001372321.1	rho GTPase-activating protein 27 isoform m
NM_001385393.1	NP_001372322.1	rho GTPase-activating protein 27 isoform n
NM_001385394.1	NP_001372323.1	rho GTPase-activating protein 27 isoform o
NM_001385395.1	NP_001372324.1	rho GTPase-activating protein 27 isoform p
NM_001385396.1	NP_001372325.1	rho GTPase-activating protein 27 isoform q
NM_001385397.1	NP_001372326.1	rho GTPase-activating protein 27 isoform r
NM_001385398.1	NP_001372327.1	rho GTPase-activating protein 27 isoform s
NM_001385399.1	NP_001372328.1	rho GTPase-activating protein 27 isoform s
NM_174919.4	NP_777579.2	rho GTPase-activating protein 27 isoform c
NM_199282.3	NP_954976.1	rho GTPase-activating protein 27 isoform a

ARHGAP27 Protein Structure

RhoGAP

0
200
400
600
800
889 a.a.

Protein Preferred Names

Protein Names

rho GTPase-activating protein 27

CIN85-associated multi-domain-containing Rho GTPase-activating protein 1

Related Diseases

Diseases

Alias

Kanzaki Disease

Alpha-N-Acetylgalactosaminidase Deficiency Type 2	Naga Deficiency Type 2
Schindler Disease, Type Ii	Adult-Onset Alpha-N-Acetylgalactosaminidase Deficiency
Schindler Disease Type 2	Alpha-N-Acetylgalactosaminidase Deficiency, Type Ii
Alpha-N-Acetylgalactosaminidase Deficiency, Adult-Onset	Naga Deficiency, Type Ii
Alpha-N-Acetylgalactosaminidase Deficiency Adult Onset	KANZD
Naga Deficiency Type Ii	Schindler Disease Type Ii

Schindler Disease

Alpha-N-Acetylgalactosaminidase Deficiency	Naga Deficiency
Alpha-Galactosidase B Deficiency	Alpha-Galnac Deficiency, Schindler Type
Alpha-Naga Deficiency	Angiokeratoma Corporis Diffusum-Glycopeptiduria
Galb Deficiency	Kanzaki Disease
Lysosomal Glycoaminoacid Storage Disease-Angiokeratoma Corporis Diffusum	Neuroaxonal Dystrophy, Schindler Type
Neuronal Axonal Dystrophy, Schindler Type	Schindler Disease, Type I
Schindler Disease, Type Ii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00927	ARHGAP27 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ARHGAP27	VGNC	VGNC:26085
Mus musculus	ARHGAP27	MGD	MGI:1916903
Macaca mulatta	ARHGAP27	VGNC	VGNC:69935
Rattus norvegicus	ARHGAP27	RGD	RGD:735202
Felis catus	ARHGAP27	VGNC	VGNC:59884

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