ZBTB7C - zinc finger and BTB domain containing 7C Gene

Also Known as APM1; APM-1; ZBTB36; ZNF857C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 201501

About ZBTB7C

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:48,026,672-48,412,585 (from NCBI)

This gene has 28 transcripts (splice variants), 201 orthologues and 36 paralogues. Broad expression in esophagus (RPKM 8.6), skin (RPKM 4.3) and 18 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of cell population proliferation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZBTB7C Products (9)

mRNA Protein Name
NM_001039360.3 NP_001034449.1 zinc finger and BTB domain-containing protein 7C
NM_001318841.2 NP_001305770.1 zinc finger and BTB domain-containing protein 7C
NM_001371284.1 NP_001358213.1 zinc finger and BTB domain-containing protein 7C
NM_001371285.1 NP_001358214.1 zinc finger and BTB domain-containing protein 7C
NM_001371286.1 NP_001358215.1 zinc finger and BTB domain-containing protein 7C
NM_001371287.1 NP_001358216.1 zinc finger and BTB domain-containing protein 7C
NM_001371288.1 NP_001358217.1 zinc finger and BTB domain-containing protein 7C
NM_001371290.1 NP_001358219.1 zinc finger and BTB domain-containing protein 7C
NM_001371291.1 NP_001358220.1 zinc finger and BTB domain-containing protein 7C

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
9427755 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB7C Protein Structure

BTB

BTB: BTB/POZ domain (24 - 127)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (381 - 402)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (407 - 431)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (434 - 459)

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  • 619 a.a.
Protein Preferred Names Protein Names

zinc finger and BTB domain-containing protein 7C

  • B230208J24Rik

Related Diseases

Diseases Alias
L-2-Hydroxyglutaric Aciduria

  • L-2-Hydroxyglutaric Acidemia

  • L2HGA

  • L-2-Hga

  • Aciduria, L-2-Hydroxyglutaric

  • Combined D-2- And L-2-Hydroxyglutaric Aciduria
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15981 ZBTB7C Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ZBTB7C VGNC VGNC:67176
Mus musculus ZBTB7C MGD MGI:2443302
Macaca mulatta ZBTB7C VGNC VGNC:104258
Canis familiaris ZBTB7C VGNC VGNC:58346
Rattus norvegicus ZBTB7C RGD RGD:1591841
Bos taurus ZBTB7C VGNC VGNC:37091
Others ZBTB7C NCBI