Scn1b - sodium channel, voltage-gated, type I, beta Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20266

Summary

Enables Sodium Channel Inhibitor activity and voltage-gated Sodium Channel activity involved in cardiac muscle cell action potential. Involved in several processes, including membrane depolarization during cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization; and sodium ion transmembrane transport. Acts upstream of or within corticospinal neuron axon guidance; neuronal action potential propagation; and positive regulation of neuron projection development. Located in T-tubule; intercalated disc; and node of Ranvier. Part of Sodium Channel complex. Is expressed in heart. Used to study generalized epilepsy with febrile seizures plus. Human ortholog(s) of this gene implicated in Brugada syndrome 5; developmental and epileptic encephalopathy 52; familial atrial fibrillation; and generalized epilepsy with febrile seizures plus 1. Orthologous to human SCN1B (sodium voltage-gated channel beta subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Scn1b Products (2)

mRNA	Protein	Name
NM_001402334.1	NP_001389263.1	sodium channel subunit beta-1 isoform 2
NM_011322.4	NP_035452.1	sodium channel subunit beta-1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15272007	MGI
enables sodium channel inhibitor activity	IMP IMP: Inferred from mutant phenotype	17884088	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	18354028	MGI
involved in cardiac conduction	IMP IMP: Inferred from mutant phenotype	17884088	MGI
acts upstream of or within corticospinal neuron axon guidance	IMP IMP: Inferred from mutant phenotype	18354028	MGI
acts upstream of or within locomotion	IMP IMP: Inferred from mutant phenotype	15102918	MGI
involved in membrane depolarization during cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	17884088	MGI
acts upstream of neuron projection development	IGI IGI: Inferred from genetic interaction	18354028	MGI
acts upstream of or within neuronal action potential propagation	IMP IMP: Inferred from mutant phenotype	15102918	MGI
acts upstream of or within positive regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	18354028	MGI
involved in regulation of sodium ion transport	IMP IMP: Inferred from mutant phenotype	17884088	MGI
involved in regulation of ventricular cardiac muscle cell membrane repolarization	IMP IMP: Inferred from mutant phenotype	17884088	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in T-tubule	IDA IDA: Inferred from direct assay	15272007	MGI
located in intercalated disc	IDA IDA: Inferred from direct assay	15272007	MGI
located in node of Ranvier	IDA IDA: Inferred from direct assay	15102918	MGI
part of sodium channel complex	IPI IPI: Inferred from physical interaction	15272007	MGI
part of voltage-gated sodium channel complex	IDA IDA: Inferred from direct assay	17884088	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
sodium channel subunit beta-1	sodium channel, voltage-gated, type I, beta polypeptide

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12528	SCN1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22797	Scn1b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29311	Scn1b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scn1b	NCBI	NCBI:6324