Scnn1a - sodium channel, nonvoltage-gated 1 alpha Gene

Also Known as ENaC; SCNEA; Scnn1; mENaC

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20276

Summary

Enables WW domain binding activity and ligand-gated Sodium Channel activity. Contributes to Sodium Channel activity. Acts upstream of or within cellular response to aldosterone and sodium ion transport. Located in cytosol and external side of plasma membrane. Is integral component of membrane. Part of plasma membrane protein complex and Sodium Channel complex. Is expressed in several structures, including colon; heart; hindgut; liver; and lung. Human ortholog(s) of this gene implicated in Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; bronchiectasis 2; and pseudohypoaldosteronism. Orthologous to human SCNN1A (Sodium Channel epithelial 1 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Scnn1a Products (3)

mRNA Protein Name
NM_001406028.1 NP_001392957.1 amiloride-sensitive sodium channel subunit alpha isoform 2
NM_001406031.1 NP_001392960.1 amiloride-sensitive sodium channel subunit alpha isoform 2
NM_011324.3 NP_035454.3 amiloride-sensitive sodium channel subunit alpha isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables WW domain binding IPI
IPI: Inferred from physical interaction
10212229 MGI
enables ligand-gated sodium channel activity IDA
IDA: Inferred from direct assay
10409305 MGI
enables ligand-gated sodium channel activity IGI
IGI: Inferred from genetic interaction
17715136 MGI
contributes to sodium channel activity IDA
IDA: Inferred from direct assay
16941024 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to aldosterone IDA
IDA: Inferred from direct assay
20427473 MGI
involved in intracellular sodium ion homeostasis IDA
IDA: Inferred from direct assay
15096495 MGI
involved in sodium ion import across plasma membrane IDA
IDA: Inferred from direct assay
15096495 MGI
acts upstream of or within sodium ion transport IDA
IDA: Inferred from direct assay
10409305 MGI
acts upstream of or within sodium ion transport IGI
IGI: Inferred from genetic interaction
16941024 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
21413931 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
17715136 MGI
located in membrane IDA
IDA: Inferred from direct assay
10409305 MGI
part of sodium channel complex IDA
IDA: Inferred from direct assay
10232677 MGI
part of sodium channel complex IGI
IGI: Inferred from genetic interaction
17715136 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

amiloride-sensitive sodium channel subunit alpha

  • ENaC alpha

  • alpha-ENaC

  • alpha-NaCH

  • amiloride-sensitive epithelial sodium channel

  • epithelial Na(+) channel subunit alpha

  • epithelial sodium channel alpha subunit

  • nonvoltage-gated sodium channel 1 subunit alpha

  • sodium channel, nonvoltage-gated, type I,

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12552 SCNN1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scnn1a NCBI NCBI:6337