Scnn1a - sodium channel, nonvoltage-gated 1 alpha Gene

Mus musculus

Also known as ENaC; SCNEA; Scnn1; mENaC

Gene ID: 20276 | Gene type: protein coding

About Scnn1a

Summary

Enables WW domain binding activity and ligand-gated Sodium Channel activity. Contributes to Sodium Channel activity. Acts upstream of or within cellular response to aldosterone and sodium ion transport. Located in cytosol and external side of plasma membrane. Is integral component of membrane. Part of plasma membrane protein complex and Sodium Channel complex. Is expressed in several structures, including colon; heart; hindgut; liver; and lung. Human ortholog(s) of this gene implicated in Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; bronchiectasis 2; and pseudohypoaldosteronism. Orthologous to human SCNN1A (Sodium Channel epithelial 1 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Scnn1a Products(3)

mRNA	Protein	Name
NM_001406028.1	NP_001392957.1	amiloride-sensitive sodium channel subunit alpha isoform 2
NM_001406031.1	NP_001392960.1	amiloride-sensitive sodium channel subunit alpha isoform 2
NM_011324.3	NP_035454.3	amiloride-sensitive sodium channel subunit alpha isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables WW domain binding	IPI IPI: Inferred from physical interaction	10212229	MGI
enables ligand-gated sodium channel activity	IDA IDA: Inferred from direct assay	10409305	MGI
enables ligand-gated sodium channel activity	IGI IGI: Inferred from genetic interaction	17715136	MGI
contributes to sodium channel activity	IDA IDA: Inferred from direct assay	16941024	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to aldosterone	IDA IDA: Inferred from direct assay	20427473	MGI
involved in intracellular sodium ion homeostasis	IDA IDA: Inferred from direct assay	15096495	MGI
involved in sodium ion import across plasma membrane	IDA IDA: Inferred from direct assay	15096495	MGI
acts upstream of or within sodium ion transport	IDA IDA: Inferred from direct assay	10409305	MGI
acts upstream of or within sodium ion transport	IGI IGI: Inferred from genetic interaction	16941024	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	21413931	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	17715136	MGI
located in membrane	IDA IDA: Inferred from direct assay	10409305	MGI
part of sodium channel complex	IDA IDA: Inferred from direct assay	10232677	MGI
part of sodium channel complex	IGI IGI: Inferred from genetic interaction	17715136	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

amiloride-sensitive sodium channel subunit alpha

ENaC alpha	alpha-ENaC
alpha-NaCH	amiloride-sensitive epithelial sodium channel
epithelial Na(+) channel subunit alpha	epithelial sodium channel alpha subunit
nonvoltage-gated sodium channel 1 subunit alpha	sodium channel, nonvoltage-gated, type I,

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12552	SCNN1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scnn1a	NCBI	NCBI:6337

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