Scnn1b - sodium channel, nonvoltage-gated 1 beta Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20277

Summary

Enables WW domain binding activity and ligand-gated Sodium Channel activity. Contributes to Sodium Channel activity. Acts upstream of or within several processes, including cellular response to aldosterone; leukocyte activation involved in inflammatory response; and monovalent inorganic cation homeostasis. Located in external side of plasma membrane. Is integral component of membrane. Part of plasma membrane protein complex and Sodium Channel complex. Is expressed in several structures, including aorta; endocrine gland; genitourinary system; lung; and stomach. Used to study Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; and cystic fibrosis. Human ortholog(s) of this gene implicated in Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; bronchiectasis 1; and pseudohypoaldosteronism. Orthologous to human SCNN1B (Sodium Channel epithelial 1 subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Scnn1b Products (2)

mRNA Protein Name
NM_001272023.1 NP_001258952.1 amiloride-sensitive sodium channel subunit beta
NM_011325.2 NP_035455.1 amiloride-sensitive sodium channel subunit beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables WW domain binding IPI
IPI: Inferred from physical interaction
10212229 MGI
enables ligand-gated sodium channel activity IDA
IDA: Inferred from direct assay
10409305 MGI
enables ligand-gated sodium channel activity IGI
IGI: Inferred from genetic interaction
17715136 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17544362 MGI
contributes to sodium channel activity IDA
IDA: Inferred from direct assay
16941024 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within aldosterone metabolic process IMP
IMP: Inferred from mutant phenotype
28567665 MGI
acts upstream of or within artery smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
19553501 MGI
acts upstream of or within cellular response to aldosterone IDA
IDA: Inferred from direct assay
20427473 MGI
acts upstream of or within epithelial fluid transport IMP
IMP: Inferred from mutant phenotype
17430990 MGI
acts upstream of or within erythrocyte homeostasis IMP
IMP: Inferred from mutant phenotype
28567665 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
18024719 MGI
involved in intracellular sodium ion homeostasis IDA
IDA: Inferred from direct assay
15096495 MGI
acts upstream of or within leukocyte activation involved in inflammatory response IDA
IDA: Inferred from direct assay
22419116 MGI
acts upstream of or within leukocyte activation involved in inflammatory response IGI
IGI: Inferred from genetic interaction
22419116 MGI
acts upstream of or within mucus secretion IDA
IDA: Inferred from direct assay
22419116 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
28567665 MGI
acts upstream of or within multicellular organismal-level water homeostasis IMP
IMP: Inferred from mutant phenotype
17430990 MGI
acts upstream of or within neutrophil activation involved in immune response IDA
IDA: Inferred from direct assay
22419116 MGI
acts upstream of or within neutrophil activation involved in immune response IGI
IGI: Inferred from genetic interaction
22419116 MGI
acts upstream of or within neutrophil-mediated killing of bacterium IDA
IDA: Inferred from direct assay
22419116 MGI
acts upstream of or within neutrophil-mediated killing of bacterium IGI
IGI: Inferred from genetic interaction
22419116 MGI
acts upstream of or within potassium ion homeostasis IMP
IMP: Inferred from mutant phenotype
28567665 MGI
acts upstream of or within renal system process IMP
IMP: Inferred from mutant phenotype
28567665 MGI
acts upstream of or within response to food IMP
IMP: Inferred from mutant phenotype
28567665 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
17430990 MGI
acts upstream of or within sodium ion homeostasis IMP
IMP: Inferred from mutant phenotype
28567665 MGI
involved in sodium ion import across plasma membrane IDA
IDA: Inferred from direct assay
15096495 MGI
acts upstream of or within sodium ion transport IDA
IDA: Inferred from direct assay
10409305 MGI
acts upstream of or within sodium ion transport IGI
IGI: Inferred from genetic interaction
16941024 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
17715136 MGI
located in membrane IDA
IDA: Inferred from direct assay
10409305 MGI
part of sodium channel complex IDA
IDA: Inferred from direct assay
32079677 MGI
part of sodium channel complex IGI
IGI: Inferred from genetic interaction
17715136 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

amiloride-sensitive sodium channel subunit beta

  • ENaC beta

  • SCNEB

  • beta-ENaC

  • beta-NaCH

  • epithelial Na(+) channel subunit beta

  • nonvoltage-gated sodium channel 1 subunit beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12553 SCNN1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scnn1b NCBI NCBI:6338