Scnn1b - sodium channel, nonvoltage-gated 1 beta Gene

Mus musculus

Gene ID: 20277 | Gene type: protein coding

About Scnn1b

Summary

Enables WW domain binding activity and ligand-gated Sodium Channel activity. Contributes to Sodium Channel activity. Acts upstream of or within several processes, including cellular response to aldosterone; leukocyte activation involved in inflammatory response; and monovalent inorganic cation homeostasis. Located in external side of plasma membrane. Is integral component of membrane. Part of plasma membrane protein complex and Sodium Channel complex. Is expressed in several structures, including aorta; endocrine gland; genitourinary system; lung; and stomach. Used to study Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; and cystic fibrosis. Human ortholog(s) of this gene implicated in Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; bronchiectasis 1; and pseudohypoaldosteronism. Orthologous to human SCNN1B (Sodium Channel epithelial 1 subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Scnn1b Products(2)

mRNA	Protein	Name
NM_001272023.1	NP_001258952.1	amiloride-sensitive sodium channel subunit beta
NM_011325.2	NP_035455.1	amiloride-sensitive sodium channel subunit beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables WW domain binding	IPI IPI: Inferred from physical interaction	10212229	MGI
enables ligand-gated sodium channel activity	IDA IDA: Inferred from direct assay	10409305	MGI
enables ligand-gated sodium channel activity	IGI IGI: Inferred from genetic interaction	17715136	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17544362	MGI
contributes to sodium channel activity	IDA IDA: Inferred from direct assay	16941024	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within aldosterone metabolic process	IMP IMP: Inferred from mutant phenotype	28567665	MGI
acts upstream of or within artery smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	19553501	MGI
acts upstream of or within cellular response to aldosterone	IDA IDA: Inferred from direct assay	20427473	MGI
acts upstream of or within epithelial fluid transport	IMP IMP: Inferred from mutant phenotype	17430990	MGI
acts upstream of or within erythrocyte homeostasis	IMP IMP: Inferred from mutant phenotype	28567665	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	18024719	MGI
involved in intracellular sodium ion homeostasis	IDA IDA: Inferred from direct assay	15096495	MGI
acts upstream of or within leukocyte activation involved in inflammatory response	IDA IDA: Inferred from direct assay	22419116	MGI
acts upstream of or within leukocyte activation involved in inflammatory response	IGI IGI: Inferred from genetic interaction	22419116	MGI
acts upstream of or within mucus secretion	IDA IDA: Inferred from direct assay	22419116	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	28567665	MGI
acts upstream of or within multicellular organismal-level water homeostasis	IMP IMP: Inferred from mutant phenotype	17430990	MGI
acts upstream of or within neutrophil activation involved in immune response	IDA IDA: Inferred from direct assay	22419116	MGI
acts upstream of or within neutrophil activation involved in immune response	IGI IGI: Inferred from genetic interaction	22419116	MGI
acts upstream of or within neutrophil-mediated killing of bacterium	IDA IDA: Inferred from direct assay	22419116	MGI
acts upstream of or within neutrophil-mediated killing of bacterium	IGI IGI: Inferred from genetic interaction	22419116	MGI
acts upstream of or within potassium ion homeostasis	IMP IMP: Inferred from mutant phenotype	28567665	MGI
acts upstream of or within renal system process	IMP IMP: Inferred from mutant phenotype	28567665	MGI
acts upstream of or within response to food	IMP IMP: Inferred from mutant phenotype	28567665	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	17430990	MGI
acts upstream of or within sodium ion homeostasis	IMP IMP: Inferred from mutant phenotype	28567665	MGI
involved in sodium ion import across plasma membrane	IDA IDA: Inferred from direct assay	15096495	MGI
acts upstream of or within sodium ion transport	IDA IDA: Inferred from direct assay	10409305	MGI
acts upstream of or within sodium ion transport	IGI IGI: Inferred from genetic interaction	16941024	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	17715136	MGI
located in membrane	IDA IDA: Inferred from direct assay	10409305	MGI
part of sodium channel complex	IDA IDA: Inferred from direct assay	32079677	MGI
part of sodium channel complex	IGI IGI: Inferred from genetic interaction	17715136	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

amiloride-sensitive sodium channel subunit beta

ENaC beta	SCNEB
beta-ENaC	beta-NaCH
epithelial Na(+) channel subunit beta	nonvoltage-gated sodium channel 1 subunit beta

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12553	SCNN1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scnn1b	NCBI	NCBI:6338

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