Scnn1g - sodium channel, nonvoltage-gated 1 gamma Gene

Also Known as SCNEG

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20278

Summary

This gene encodes the gamma subunit of the epithelial Sodium Channel, a member of the amiloride-sensitive Sodium Channel family of proteins. This channel regulates sodium homeostasis and blood pressure, by controlling sodium transport in the kidney, colon and lung. Proteolytic processing of the encoded protein results in the release of an inhibitory peptide and channel activation. Homozygous knockout mice for this gene exhibit perinatal lethality, likely due to excess serum potassium. [provided by RefSeq, Oct 2015]

Scnn1g Products (1)

mRNA Protein Name
NM_011326.3 NP_035456.1 amiloride-sensitive sodium channel subunit gamma

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables WW domain binding IPI
IPI: Inferred from physical interaction
10212229 MGI
enables ligand-gated sodium channel activity IDA
IDA: Inferred from direct assay
10409305 MGI
enables ligand-gated sodium channel activity IGI
IGI: Inferred from genetic interaction
17715136 MGI
contributes to sodium channel activity IDA
IDA: Inferred from direct assay
16941024 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to aldosterone IDA
IDA: Inferred from direct assay
20427473 MGI
involved in intracellular sodium ion homeostasis IDA
IDA: Inferred from direct assay
15096495 MGI
involved in sodium ion import across plasma membrane IDA
IDA: Inferred from direct assay
15096495 MGI
acts upstream of or within sodium ion transport IDA
IDA: Inferred from direct assay
10409305 MGI
acts upstream of or within sodium ion transport IGI
IGI: Inferred from genetic interaction
16941024 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
17715136 MGI
located in membrane IDA
IDA: Inferred from direct assay
10409305 MGI
part of sodium channel complex IDA
IDA: Inferred from direct assay
10232677 MGI
part of sodium channel complex IGI
IGI: Inferred from genetic interaction
17715136 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

amiloride-sensitive sodium channel subunit gamma

  • ENaC gamma

  • epithelial Na(+) channel subunit gamma

  • gamma-ENaC

  • gamma-NaCH

  • nonvoltage-gated sodium channel 1 subunit gamma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12555 SCNN1G Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scnn1g NCBI NCBI:6340