Scnn1g - sodium channel, nonvoltage-gated 1 gamma Gene

Mus musculus

Also known as SCNEG

Gene ID: 20278 | Gene type: protein coding

About Scnn1g

Summary

This gene encodes the gamma subunit of the epithelial Sodium Channel, a member of the amiloride-sensitive Sodium Channel family of proteins. This channel regulates sodium homeostasis and blood pressure, by controlling sodium transport in the kidney, colon and lung. Proteolytic processing of the encoded protein results in the release of an inhibitory peptide and channel activation. Homozygous knockout mice for this gene exhibit perinatal lethality, likely due to excess serum potassium. [provided by RefSeq, Oct 2015]

Scnn1g Products(1)

mRNA	Protein	Name
NM_011326.3	NP_035456.1	amiloride-sensitive sodium channel subunit gamma

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables WW domain binding	IPI IPI: Inferred from physical interaction	10212229	MGI
enables ligand-gated sodium channel activity	IDA IDA: Inferred from direct assay	10409305	MGI
enables ligand-gated sodium channel activity	IGI IGI: Inferred from genetic interaction	17715136	MGI
contributes to sodium channel activity	IDA IDA: Inferred from direct assay	16941024	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to aldosterone	IDA IDA: Inferred from direct assay	20427473	MGI
involved in intracellular sodium ion homeostasis	IDA IDA: Inferred from direct assay	15096495	MGI
involved in sodium ion import across plasma membrane	IDA IDA: Inferred from direct assay	15096495	MGI
acts upstream of or within sodium ion transport	IDA IDA: Inferred from direct assay	10409305	MGI
acts upstream of or within sodium ion transport	IGI IGI: Inferred from genetic interaction	16941024	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	17715136	MGI
located in membrane	IDA IDA: Inferred from direct assay	10409305	MGI
part of sodium channel complex	IDA IDA: Inferred from direct assay	10232677	MGI
part of sodium channel complex	IGI IGI: Inferred from genetic interaction	17715136	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

amiloride-sensitive sodium channel subunit gamma

ENaC gamma	epithelial Na(+) channel subunit gamma
gamma-ENaC	gamma-NaCH
nonvoltage-gated sodium channel 1 subunit gamma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12555	SCNN1G Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scnn1g	NCBI	NCBI:6340

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