Sema3c - sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C Gene

Also Known as SemE; Semae; 1110036B02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20348

Summary

Enables semaphorin receptor binding activity. Involved in several processes, including cardiac endothelial to mesenchymal transition; outflow tract septum morphogenesis; and positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis. Acts upstream of or within several processes, including chordate embryonic development; circulatory system development; and dichotomous subdivision of terminal units involved in salivary gland branching. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Orthologous to human SEMA3C (semaphorin 3C). [provided by Alliance of Genome Resources, Apr 2022]

Sema3c Products (1)

mRNA Protein Name
NM_013657.5 NP_038685.3 semaphorin-3C precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables semaphorin receptor binding IPI
IPI: Inferred from physical interaction
15239958 MGI
Biological Process GO Annotation Evidence References Source
involved in axon guidance IDA
IDA: Inferred from direct assay
17021275 MGI
acts upstream of or within blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
11688556 MGI
involved in cardiac endothelial to mesenchymal transition IDA
IDA: Inferred from direct assay
26053665 MGI
involved in cardiac right ventricle morphogenesis IEP
IEP: Inferred from expression pattern
19666519 MGI
acts upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching IDA
IDA: Inferred from direct assay
17626059 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
11688556 MGI
involved in limb bud formation IEP
IEP: Inferred from expression pattern
19666519 MGI
acts upstream of or within neural crest cell migration IMP
IMP: Inferred from mutant phenotype
11688556 MGI
involved in neural tube development IEP
IEP: Inferred from expression pattern
19666519 MGI
involved in outflow tract morphogenesis IEP
IEP: Inferred from expression pattern
19666519 MGI
involved in outflow tract septum morphogenesis IGI
IGI: Inferred from genetic interaction
26053665 MGI
involved in outflow tract septum morphogenesis IMP
IMP: Inferred from mutant phenotype
26053665 MGI
involved in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis IDA
IDA: Inferred from direct assay
26053665 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
11688556 MGI
involved in pulmonary myocardium development IEP
IEP: Inferred from expression pattern
19666519 MGI
involved in semaphorin-plexin signaling pathway IMP
IMP: Inferred from mutant phenotype
26053665 MGI
involved in somitogenesis IEP
IEP: Inferred from expression pattern
19666519 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
15239958 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

semaphorin-3C

  • sema E

  • semaphorin E

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12652 SEMA3C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19812 Sema3c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26308 Sema3c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sema3c NCBI NCBI:10512