Sema3e - sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E Gene

Also Known as Semah; mKIAA0331; 6430702L12

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20349

Summary

Enables semaphorin receptor binding activity. Involved in several processes, including angiogenesis; negative regulation of angiogenesis; and regulation of actin Cytoskeleton reorganization. Located in extracellular space. Is expressed in several structures, including hemolymphoid system gland; nervous system; nose; palatal shelf mesenchyme; and trunk mesenchyme. Human ortholog(s) of this gene implicated in CHARGE syndrome. Orthologous to human SEMA3E (semaphorin 3E). [provided by Alliance of Genome Resources, Apr 2022]

Sema3e Products (2)

mRNA Protein Name
NM_011348.2 NP_035478.2 semaphorin-3E precursor
NM_011348.2 NP_035478.2 semaphorin-3E precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24139859 MGI
enables semaphorin receptor binding IPI
IPI: Inferred from physical interaction
24841563 MGI
Biological Process GO Annotation Evidence References Source
involved in branching involved in blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
15550623 MGI
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
20385769 MGI
involved in negative regulation of cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
20385769 MGI
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
15550623 MGI
involved in semaphorin-plexin signaling pathway IMP
IMP: Inferred from mutant phenotype
15550623 MGI
involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
20385769 MGI
involved in synapse organization IMP
IMP: Inferred from mutant phenotype
22179111 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

semaphorin-3E

  • sema H

  • semaphorin-H

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12654 SEMA3E Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sema3e NCBI NCBI:9723