Sema3e - sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E Gene

Mus musculus

Also known as Semah; mKIAA0331; 6430702L12

Gene ID: 20349 | Gene type: protein coding

About Sema3e

Summary

Enables semaphorin receptor binding activity. Involved in several processes, including angiogenesis; negative regulation of angiogenesis; and regulation of actin Cytoskeleton reorganization. Located in extracellular space. Is expressed in several structures, including hemolymphoid system gland; nervous system; nose; palatal shelf mesenchyme; and trunk mesenchyme. Human ortholog(s) of this gene implicated in CHARGE syndrome. Orthologous to human SEMA3E (semaphorin 3E). [provided by Alliance of Genome Resources, Apr 2022]

Sema3e Products(2)

mRNA	Protein	Name
NM_011348.2	NP_035478.2	semaphorin-3E precursor
NM_011348.2	NP_035478.2	semaphorin-3E precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24139859	MGI
enables semaphorin receptor binding	IPI IPI: Inferred from physical interaction	24841563	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	15550623	MGI
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	20385769	MGI
involved in negative regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	20385769	MGI
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	15550623	MGI
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	15550623	MGI
involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	20385769	MGI
involved in synapse organization	IMP IMP: Inferred from mutant phenotype	22179111	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

semaphorin-3E

sema H

semaphorin-H

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12654	SEMA3E Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sema3e	NCBI	NCBI:9723

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