Sema6a - sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A Gene

Also Known as VIa; Semaq; Sema6A-1; A730020P05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20358

Summary

Enables identical protein binding activity; semaphorin receptor binding activity; and transmembrane signaling receptor activity. Involved in generation of neurons; positive regulation of neuron migration; and semaphorin-plexin signaling pathway. Acts upstream of or within cell surface receptor signaling pathway and centrosome localization. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; limb mesenchyme; nervous system; and sensory organ. Orthologous to human SEMA6A (semaphorin 6A). [provided by Alliance of Genome Resources, Apr 2022]

Sema6a Products (2)

mRNA Protein Name
NM_001311097.1 NP_001298026.1 semaphorin-6A isoform 2 precursor
NM_018744.2 NP_061214.2 semaphorin-6A isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
20877282 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10993894 MGI
enables semaphorin receptor binding IGI
IGI: Inferred from genetic interaction
18327254 MGI
enables semaphorin receptor binding IPI
IPI: Inferred from physical interaction
15814794 MGI
enables transmembrane signaling receptor activity IMP
IMP: Inferred from mutant phenotype
20877282 MGI
Biological Process GO Annotation Evidence References Source
involved in axon guidance IMP
IMP: Inferred from mutant phenotype
16205717 MGI
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
18327254 MGI
acts upstream of or within centrosome localization IMP
IMP: Inferred from mutant phenotype
18327254 MGI
involved in neuron migration IMP
IMP: Inferred from mutant phenotype
16205717 MGI
involved in positive regulation of neuron migration IMP
IMP: Inferred from mutant phenotype
20877282 MGI
involved in semaphorin-plexin signaling pathway IMP
IMP: Inferred from mutant phenotype
20877282 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
20877282 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

semaphorin-6A

  • Mutant line 997

  • sema Q

  • sema VIA

  • semaphorin Q

  • semaphorin VIA

  • semaphorin-6A-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12665 SEMA6A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21192 Sema6a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27708 Sema6a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sema6a NCBI NCBI:57556