Sh3gl2 - SH3-domain GRB2-like 2 Gene

Mus musculus

Also known as EEN1; SH3PA; EEN-B1; Sh3d2a; 9530001L19Rik; B930049H17Rik

Gene ID: 20404 | Gene type: protein coding

About Sh3gl2

Summary

Enables identical protein binding activity. Involved in cellular response to brain-derived neurotrophic factor stimulus; dendrite extension; and synaptic vesicle uncoating. Acts upstream of or within regulation of receptor internalization and synaptic vesicle endocytosis. Located in early endosome and presynaptic cytosol. Is active in photoreceptor ribbon synapse. Is expressed in several structures, including adrenal gland; central nervous system; dorsal aorta; peripheral nervous system; and testis. Orthologous to human SH3GL2 (SH3 domain containing GRB2 like 2, endophilin A1). [provided by Alliance of Genome Resources, Apr 2022]

Sh3gl2 Products(1)

mRNA	Protein	Name
NM_019535.2	NP_062408.2	endophilin-A1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	18940612	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16164598	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to brain-derived neurotrophic factor stimulus	IMP IMP: Inferred from mutant phenotype	21849472	MGI
involved in dendrite extension	IMP IMP: Inferred from mutant phenotype	21849472	MGI
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	21849472	MGI
involved in postsynaptic actin cytoskeleton organization	IDA IDA: Inferred from direct assay	25771685	MGI
involved in postsynaptic actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	25771685	MGI
acts upstream of or within regulation of receptor internalization	IDA IDA: Inferred from direct assay	16164598	MGI
acts upstream of or within synaptic vesicle endocytosis	IGI IGI: Inferred from genetic interaction	19481455	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome	IDA IDA: Inferred from direct assay	21849472	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	25771685	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	25771685	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	25771685	MGI
is active in photoreceptor ribbon synapse	IDA IDA: Inferred from direct assay	23785143	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	25771685	MGI
is active in postsynapse	IEP IEP: Inferred from expression pattern	25771685	MGI
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	23785143	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

endophilin-A1

SH3 domain protein 2A	SH3 domain-containing GRB2-like protein 2
SH3p4	endophilin I
endophilin-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12837	SH3GL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sh3gl2	NCBI	NCBI:6456

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