Sh3gl2 - SH3-domain GRB2-like 2 Gene

Also Known as EEN1; SH3PA; EEN-B1; Sh3d2a; 9530001L19Rik; B930049H17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20404

Summary

Enables identical protein binding activity. Involved in cellular response to brain-derived neurotrophic factor stimulus; dendrite extension; and synaptic vesicle uncoating. Acts upstream of or within regulation of receptor internalization and synaptic vesicle endocytosis. Located in early endosome and presynaptic cytosol. Is active in photoreceptor ribbon synapse. Is expressed in several structures, including adrenal gland; central nervous system; dorsal aorta; peripheral nervous system; and testis. Orthologous to human SH3GL2 (SH3 domain containing GRB2 like 2, endophilin A1). [provided by Alliance of Genome Resources, Apr 2022]

Sh3gl2 Products (1)

mRNA Protein Name
NM_019535.2 NP_062408.2 endophilin-A1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
18940612 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16164598 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to brain-derived neurotrophic factor stimulus IMP
IMP: Inferred from mutant phenotype
21849472 MGI
involved in dendrite extension IMP
IMP: Inferred from mutant phenotype
21849472 MGI
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
21849472 MGI
involved in postsynaptic actin cytoskeleton organization IDA
IDA: Inferred from direct assay
25771685 MGI
involved in postsynaptic actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
25771685 MGI
acts upstream of or within regulation of receptor internalization IDA
IDA: Inferred from direct assay
16164598 MGI
acts upstream of or within synaptic vesicle endocytosis IGI
IGI: Inferred from genetic interaction
19481455 MGI
Cellular Component GO Annotation Evidence References Source
located in early endosome IDA
IDA: Inferred from direct assay
21849472 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25771685 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
25771685 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25771685 MGI
is active in photoreceptor ribbon synapse IDA
IDA: Inferred from direct assay
23785143 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
25771685 MGI
is active in postsynapse IEP
IEP: Inferred from expression pattern
25771685 MGI
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
23785143 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endophilin-A1

  • SH3 domain protein 2A

  • SH3 domain-containing GRB2-like protein 2

  • SH3p4

  • endophilin I

  • endophilin-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12837 SH3GL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sh3gl2 NCBI NCBI:6456