Sorbs3 - sorbin and SH3 domain containing 3 Gene

Also Known as SH3P3; Sh3d4; SCAM-1; vinexin-g

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20410

Summary

Predicted to enable vinculin binding activity. Acts upstream of or within cell-substrate adhesion; negative regulation of transcription by RNA polymerase II; and positive regulation of MAPK cascade. Located in cytoplasm; focal adhesion; and nucleus. Is expressed in several structures, including branchial arch; eye; gonad; heart; and hindbrain. Orthologous to human SORBS3 (sorbin and SH3 domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Sorbs3 Products (4)

mRNA Protein Name
NM_001271407.1 NP_001258336.1 vinexin isoform b
NM_001271408.1 NP_001258337.1 vinexin isoform b
NM_001271409.1 NP_001258338.1 vinexin isoform c
NM_011366.3 NP_035496.1 vinexin isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables transcription factor binding IPI
IPI: Inferred from physical interaction
15734736 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of MAPK cascade IMP
IMP: Inferred from mutant phenotype
15836771 MGI
acts upstream of or within cell-substrate adhesion IDA
IDA: Inferred from direct assay
9885244 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15734736 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15734736 MGI
acts upstream of or within positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
15836771 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9885244 MGI
located in focal adhesion IDA
IDA: Inferred from direct assay
9885244 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9885244 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vinexin

  • SH3 domain protein 4

  • SH3 domain-containing protein SH3P3

  • SH3-containing adapter molecule 1

  • vinexin alpha

  • vinexin beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13569 SORBS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sorbs3 NCBI NCBI:10174