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Shox2 - short stature homeobox 2 Gene

Also Known as OG12; Prx3; SHOT; Og12x; 6330543G17Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20429

Summary

Enables sequence-specific DNA binding activity. Involved in several processes, including heart development; positive regulation of cell development; and regulation of branching morphogenesis of a nerve. Acts upstream of or within several processes, including animal organ development; embryonic forelimb morphogenesis; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; facial prominence; genitourinary system; heart; and limb mesenchyme. Used to study Leri-Weill dyschondrosteosis. Human ortholog(s) of this gene implicated in lung Cancer. Orthologous to human SHOX2 (short stature homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Shox2 Products (4)

mRNA	Protein	Name
NM_001302357.1	NP_001289286.1	short stature homeobox protein 2 isoform 2
NM_001302358.1	NP_001289287.1	short stature homeobox protein 2 isoform 3
NM_001302359.1	NP_001289288.1	short stature homeobox protein 2 isoform 3
NM_013665.1	NP_038693.1	short stature homeobox protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23332764	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cardiac atrium morphogenesis	IMP IMP: Inferred from mutant phenotype	17372176	MGI
involved in cardiac pacemaker cell differentiation	IMP IMP: Inferred from mutant phenotype	19166829	MGI
involved in cardiac right atrium morphogenesis	IMP IMP: Inferred from mutant phenotype	19166829	MGI
acts upstream of or within cartilage development involved in endochondral bone morphogenesis	IMP IMP: Inferred from mutant phenotype	16537395	MGI
acts upstream of or within chondrocyte development	IMP IMP: Inferred from mutant phenotype	17481601	MGI
acts upstream of or within chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	22916278	MGI
acts upstream of or within embryonic digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	16141225	MGI
acts upstream of or within embryonic forelimb morphogenesis	IMP IMP: Inferred from mutant phenotype	22916278	MGI
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	16537395	MGI
acts upstream of or within embryonic morphogenesis	IMP IMP: Inferred from mutant phenotype	16141225	MGI
acts upstream of or within embryonic skeletal joint morphogenesis	IMP IMP: Inferred from mutant phenotype	18514492	MGI
acts upstream of or within heart valve development	IMP IMP: Inferred from mutant phenotype	17372176	MGI
acts upstream of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	18514492	MGI
involved in muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	21156168	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21640717	MGI
acts upstream of or within osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	18514492	MGI
involved in positive regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	21156168	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	18514492	MGI
involved in positive regulation of skeletal muscle fiber development	IMP IMP: Inferred from mutant phenotype	21156168	MGI
acts upstream of or within positive regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	17481601	MGI
acts upstream of or within positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	18514492	MGI
involved in regulation of branching morphogenesis of a nerve	IMP IMP: Inferred from mutant phenotype	21156168	MGI
acts upstream of or within regulation of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	16537395	MGI
acts upstream of regulation of heart rate	IMP IMP: Inferred from mutant phenotype	19166829	MGI
involved in sinoatrial node cell development	IMP IMP: Inferred from mutant phenotype	21640717	MGI
involved in sinoatrial node development	IMP IMP: Inferred from mutant phenotype	19166829	MGI
involved in sinoatrial valve development	IMP IMP: Inferred from mutant phenotype	19166829	MGI
acts upstream of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	17481601	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	18514492	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
short stature homeobox protein 2	OG-12 homeobox protein Og12X paired family homeodomain protein Prx3

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12880	SHOX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Shox2	NCBI	NCBI:6474