2. Gene
  3. Cyfip1 - cytoplasmic FMR1 interacting protein 1 Gene

Cyfip1 - cytoplasmic FMR1 interacting protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Shyc; Sra1; pl-1; Sra-1; l71Rl; l7Rl1; l(7)1Rl; P140sra1; P140SRA-1; mKIAA0068; E030028J09Rik

Gene ID: 20430 | Gene type: protein coding

About Cyfip1

Summary

Enables translation regulator activity. Involved in several processes, including dendrite extension; positive regulation of neurotrophin Trk Receptor signaling pathway; and regulation of modification of postsynaptic actin Cytoskeleton. Acts upstream of or within lamellipodium assembly. Located in several cellular components, including lamellipodium; perinuclear region of cytoplasm; and postsynapse. Part of mRNA cap binding activity complex. Is expressed in several structures, including embryo mesenchyme; lung; nervous system; skeletal muscle; and tooth. Human ortholog(s) of this gene implicated in autism spectrum disorder and schizophrenia. Orthologous to human CYFIP1 (cytoplasmic FMR1 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyfip1 Products(3)

mRNA Protein Name
NM_001164661.1 NP_001158133.1 cytoplasmic FMR1-interacting protein 1 isoform a
NM_001164662.1 NP_001158134.1 cytoplasmic FMR1-interacting protein 1 isoform b
NM_011370.3 NP_035500.2 cytoplasmic FMR1-interacting protein 1 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11438699 MGI
enables translation repressor activity IDA
IDA: Inferred from direct assay
18805096 MGI
Biological Process GO Annotation Evidence Reference Source
involved in dendrite extension IMP
IMP: Inferred from mutant phenotype
27605705 MGI
acts upstream of or within lamellipodium assembly IDA
IDA: Inferred from direct assay
14765121 MGI
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
27605705 MGI
involved in positive regulation of neurotrophin TRK receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
27605705 MGI
involved in regulation of modification of postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
24050404 MGI
involved in regulation of modification of postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
24050404 MGI
involved in regulation of translation at postsynapse, modulating synaptic transmission EXP
EXP: Inferred from Experiment
24050404 MGI
involved in regulation of translation at postsynapse, modulating synaptic transmission IDA
IDA: Inferred from direct assay
24050404 MGI
involved in regulation of translation at postsynapse, modulating synaptic transmission IEP
IEP: Inferred from expression pattern
24050404 MGI
involved in regulation of translation at postsynapse, modulating synaptic transmission IMP
IMP: Inferred from mutant phenotype
24050404 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cell leading edge IDA
IDA: Inferred from direct assay
16831833 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
14765121 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
11438699 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11438699 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
24050404 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytoplasmic FMR1-interacting protein 1

specifically Rac1-associated protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03430 CYFIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyfip1 NCBI NCBI:23191