Cyfip1 - cytoplasmic FMR1 interacting protein 1 Gene

Also Known as Shyc; Sra1; pl-1; Sra-1; l71Rl; l7Rl1; l(7)1Rl; P140sra1; P140SRA-1; mKIAA0068; E030028J09Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20430

Summary

Enables translation regulator activity. Involved in several processes, including dendrite extension; positive regulation of neurotrophin Trk Receptor signaling pathway; and regulation of modification of postsynaptic actin Cytoskeleton. Acts upstream of or within lamellipodium assembly. Located in several cellular components, including lamellipodium; perinuclear region of cytoplasm; and postsynapse. Part of mRNA cap binding activity complex. Is expressed in several structures, including embryo mesenchyme; lung; nervous system; skeletal muscle; and tooth. Human ortholog(s) of this gene implicated in autism spectrum disorder and schizophrenia. Orthologous to human CYFIP1 (cytoplasmic FMR1 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyfip1 Products (3)

mRNA	Protein	Name
NM_001164661.1	NP_001158133.1	cytoplasmic FMR1-interacting protein 1 isoform a
NM_001164662.1	NP_001158134.1	cytoplasmic FMR1-interacting protein 1 isoform b
NM_011370.3	NP_035500.2	cytoplasmic FMR1-interacting protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11438699	MGI
enables translation repressor activity	IDA IDA: Inferred from direct assay	18805096	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in dendrite extension	IMP IMP: Inferred from mutant phenotype	27605705	MGI
acts upstream of or within lamellipodium assembly	IDA IDA: Inferred from direct assay	14765121	MGI
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	27605705	MGI
involved in positive regulation of neurotrophin TRK receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	27605705	MGI
involved in regulation of modification of postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	24050404	MGI
involved in regulation of modification of postsynaptic actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	24050404	MGI
involved in regulation of translation at postsynapse, modulating synaptic transmission	EXP EXP: Inferred from Experiment	24050404	MGI
involved in regulation of translation at postsynapse, modulating synaptic transmission	IDA IDA: Inferred from direct assay	24050404	MGI
involved in regulation of translation at postsynapse, modulating synaptic transmission	IEP IEP: Inferred from expression pattern	24050404	MGI
involved in regulation of translation at postsynapse, modulating synaptic transmission	IMP IMP: Inferred from mutant phenotype	24050404	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell leading edge	IDA IDA: Inferred from direct assay	16831833	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	14765121	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	11438699	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11438699	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	24050404	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cytoplasmic FMR1-interacting protein 1	specifically Rac1-associated protein 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03430	CYFIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cyfip1	NCBI	NCBI:23191