Stil - Scl/Tal1 interrupting locus Gene

Mus musculus

Also known as Sil

Gene ID: 20460 | Gene type: protein coding

About Stil

Summary

This gene encodes a centrosomal protein ubiquitously expressed in proliferating cells and during early embryonic development. Mice lacking the encoded protein die in utero with marked growth retardation, defects in the developing neural fold and randomization of left-right asymmetry. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Stil Products(5)

mRNA	Protein	Name
NM_001304551.1	NP_001291480.1	SCL-interrupting locus protein homolog isoform 3
NM_001304553.1	NP_001291482.1	SCL-interrupting locus protein homolog isoform 5
NM_001304555.1	NP_001291484.1	SCL-interrupting locus protein homolog isoform 2
NM_001304559.1	NP_001291488.1	SCL-interrupting locus protein homolog isoform 4
NM_009185.3	NP_033211.2	SCL-interrupting locus protein homolog isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16024801	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	10385121	MGI
acts upstream of or within centrosome duplication	IMP IMP: Inferred from mutant phenotype	22349705	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	10385121	MGI
acts upstream of or within embryonic axis specification	IMP IMP: Inferred from mutant phenotype	10385121	MGI
acts upstream of or within floor plate development	IMP IMP: Inferred from mutant phenotype	10385121	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	10385121	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	10385121	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	10385121	MGI
acts upstream of or within mitotic spindle checkpoint signaling	IMP IMP: Inferred from mutant phenotype	16024801	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	10385121	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10385121	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	10385121	MGI
acts upstream of or within neural tube development	IMP IMP: Inferred from mutant phenotype	10385121	MGI
acts upstream of or within non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	22349705	MGI
acts upstream of or within notochord development	IMP IMP: Inferred from mutant phenotype	10385121	MGI
acts upstream of or within positive regulation of cyclin-dependent protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	16024801	MGI
acts upstream of or within smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	10385121	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

SCL-interrupting locus protein homolog

Tal1 interrupting locus

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13912	STIL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stil	NCBI	NCBI:6491

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