Stil - Scl/Tal1 interrupting locus Gene

Also Known as Sil

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20460

Summary

This gene encodes a centrosomal protein ubiquitously expressed in proliferating cells and during early embryonic development. Mice lacking the encoded protein die in utero with marked growth retardation, defects in the developing neural fold and randomization of left-right asymmetry. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Stil Products (5)

mRNA Protein Name
NM_001304551.1 NP_001291480.1 SCL-interrupting locus protein homolog isoform 3
NM_001304553.1 NP_001291482.1 SCL-interrupting locus protein homolog isoform 5
NM_001304555.1 NP_001291484.1 SCL-interrupting locus protein homolog isoform 2
NM_001304559.1 NP_001291488.1 SCL-interrupting locus protein homolog isoform 4
NM_009185.3 NP_033211.2 SCL-interrupting locus protein homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16024801 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
10385121 MGI
acts upstream of or within centrosome duplication IMP
IMP: Inferred from mutant phenotype
22349705 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
10385121 MGI
acts upstream of or within embryonic axis specification IMP
IMP: Inferred from mutant phenotype
10385121 MGI
acts upstream of or within floor plate development IMP
IMP: Inferred from mutant phenotype
10385121 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
10385121 MGI
acts upstream of or within heart looping IMP
IMP: Inferred from mutant phenotype
10385121 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
10385121 MGI
acts upstream of or within mitotic spindle checkpoint signaling IMP
IMP: Inferred from mutant phenotype
16024801 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
10385121 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
10385121 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
10385121 MGI
acts upstream of or within neural tube development IMP
IMP: Inferred from mutant phenotype
10385121 MGI
acts upstream of or within non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
22349705 MGI
acts upstream of or within notochord development IMP
IMP: Inferred from mutant phenotype
10385121 MGI
acts upstream of or within positive regulation of cyclin-dependent protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
16024801 MGI
acts upstream of or within smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
10385121 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SCL-interrupting locus protein homolog

  • Tal1 interrupting locus

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13912 STIL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Stil NCBI NCBI:6491