Sim2 - single-minded family bHLH transcription factor 2 Gene

Mus musculus

Also known as bHLHe15

Gene ID: 20465 | Gene type: protein coding

About Sim2

Summary

Enables DNA binding activity and protein heterodimerization activity. Acts upstream of or within embryonic pattern specification; lung development; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including branchial arch; future brain; genitourinary system; limb; and musculoskeletal system. Orthologous to human SIM2 (SIM bHLH transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Sim2 Products(1)

mRNA	Protein	Name
NM_011377.2	NP_035507.2	single-minded homolog 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11782478	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11782478	MGI
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	8927054	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within embryonic pattern specification	IMP IMP: Inferred from mutant phenotype	12024028	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	12024028	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11782478	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	14701734	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	11782478	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

single-minded homolog 2

SIM transcription factor	mSIM
single-minded 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12923	SIM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sim2	NCBI	NCBI:6493

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