Sim2 - single-minded family bHLH transcription factor 2 Gene

Also Known as bHLHe15

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20465

Summary

Enables DNA binding activity and protein heterodimerization activity. Acts upstream of or within embryonic pattern specification; lung development; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including branchial arch; future brain; genitourinary system; limb; and musculoskeletal system. Orthologous to human SIM2 (SIM bHLH transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Sim2 Products (1)

mRNA Protein Name
NM_011377.2 NP_035507.2 single-minded homolog 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
11782478 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11782478 MGI
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
8927054 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within embryonic pattern specification IMP
IMP: Inferred from mutant phenotype
12024028 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
12024028 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11782478 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
14701734 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
11782478 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

single-minded homolog 2

  • SIM transcription factor

  • mSIM

  • single-minded 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12923 SIM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sim2 NCBI NCBI:6493