Slc16a2 - solute carrier family 16 (monocarboxylic acid transporters), member 2 Gene

Also Known as Mct8; Xpct

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20502

Summary

Predicted to enable amino acid transmembrane transporter activity and thyroid hormone transmembrane transporter activity. Acts upstream of or within with a negative effect on thyroid hormone generation and thyroid-stimulating hormone secretion. Acts upstream of or within thyroid hormone transport. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; cochlea; and limb. Used to study Allan-Herndon-Dudley syndrome. Human ortholog(s) of this gene implicated in Allan-Herndon-Dudley syndrome and intellectual disability. Orthologous to human SLC16A2 (solute carrier family 16 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc16a2 Products (1)

mRNA Protein Name
NM_009197.2 NP_033223.2 monocarboxylate transporter 8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables thyroid hormone transmembrane transporter activity IDA
IDA: Inferred from direct assay
31436139 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative effect thyroid hormone generation IGI
IGI: Inferred from genetic interaction
24248460 MGI
acts upstream of or within negative effect thyroid hormone generation IMP
IMP: Inferred from mutant phenotype
24248460 MGI
involved in thyroid hormone transport IDA
IDA: Inferred from direct assay
31436139 MGI
acts upstream of or within thyroid hormone transport IGI
IGI: Inferred from genetic interaction
24248460 MGI
acts upstream of or within thyroid hormone transport IMP
IMP: Inferred from mutant phenotype
24248460 MGI
acts upstream of or within negative effect thyroid-stimulating hormone secretion IGI
IGI: Inferred from genetic interaction
24248460 MGI
acts upstream of or within negative effect thyroid-stimulating hormone secretion IMP
IMP: Inferred from mutant phenotype
24248460 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
18687783 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

monocarboxylate transporter 8

  • MCT 8

  • Monocarboxylate transporter 8 (MCT 8) (X-linked PEST-containing transporter)

  • X-linked PEST-containing transporter

  • solute carrier family 16 member 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13024 SLC16A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc16a2 NCBI NCBI:6567